Agomelatine-d6
Based on 1 Customer Validation
Agomelatine-d6 is deuterium labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors .
For research use only. We do not sell to patients.
- Purity: 99.05%
- CAS No.: 1079389-42-6
- Formula: C15H11D6NO2
- Molecular Weight:249.34
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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MT2 |
MT1 |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1079389-42-6
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Unlabeled Cas 138112-76-2
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Appearance Solid
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Molecular Weight 249.34
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Formula C15H11D6NO2
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Color Off-white to light yellow
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SMILES
O=C(NCCC1=C2C=C(OC([2H])([2H])[2H])C=CC2=CC=C1)C([2H])([2H])[2H]
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Synonyms
S-20098-d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (401.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (10.03 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (10.03 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (540 KB)
- English - EN (540 KB)
- Français - FR (540 KB)
- Deutsch - DE (540 KB)
- Norwegian - NO (540 KB)
- Español - ES (540 KB)
- Swedish - SV (540 KB)
- Italian - IT (540 KB)
- Korean - KR (540 KB)
- Portuguese - PT (540 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0106 mL | 20.0529 mL | 40.1059 mL | 100.2647 mL |
| 5 mM | 0.8021 mL | 4.0106 mL | 8.0212 mL | 20.0529 mL | |
| 10 mM | 0.4011 mL | 2.0053 mL | 4.0106 mL | 10.0265 mL | |
| 15 mM | 0.2674 mL | 1.3369 mL | 2.6737 mL | 6.6843 mL | |
| 20 mM | 0.2005 mL | 1.0026 mL | 2.0053 mL | 5.0132 mL | |
| 25 mM | 0.1604 mL | 0.8021 mL | 1.6042 mL | 4.0106 mL | |
| 30 mM | 0.1337 mL | 0.6684 mL | 1.3369 mL | 3.3422 mL | |
| 40 mM | 0.1003 mL | 0.5013 mL | 1.0026 mL | 2.5066 mL | |
| 50 mM | 0.0802 mL | 0.4011 mL | 0.8021 mL | 2.0053 mL | |
| 60 mM | 0.0668 mL | 0.3342 mL | 0.6684 mL | 1.6711 mL | |
| 80 mM | 0.0501 mL | 0.2507 mL | 0.5013 mL | 1.2533 mL | |
| 100 mM | 0.0401 mL | 0.2005 mL | 0.4011 mL | 1.0026 mL |
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