PIM2 - Pim-2 proto-oncogene, serine/threonine kinase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11040

About PIM2

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,913,182-48,919,024 (from NCBI)

This gene has 3 transcripts (splice variants), 115 orthologues and 2 paralogues. Broad expression in lymph node (RPKM 45.7), appendix (RPKM 40.1) and 20 other tissues.

Summary

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent Apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]

PIM2 Products (2)

mRNA Protein Name
NM_006875.4 NP_006866.2 serine/threonine-protein kinase pim-2
XM_047441792.1 XP_047297748.1 serine/threonine-protein kinase pim-2 isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18593906 GOA
Biological Process GO Annotation Evidence References Source
involved in G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
20307683 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
18675992 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
20307683 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
18593906 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
20307683 GOA
involved in response to virus IEP
IEP: Inferred from expression pattern
16548883 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIM2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (32 - 286)

  • 0
  • 100
  • 200
  • 311 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase pim-2

  • pim-2 oncogene

  • pim-2h

  • proto-oncogene Pim-2 (serine threonine kinase)

PIM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PIM2 Q9P1W9 ZNF821 Homo sapiens O75541
Y2H Prey Pooling
25416956
Intra
PIM2 Q9P1W9 ATXN1 Homo sapiens P54253
Y2H Array
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

PIM2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83005 PIM2 Antibody (YA2750) WB, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Colorectal Adenocarcinoma

  • Adenocarcinoma Of Large Intestine
Myeloid Leukemia

  • Myeloid Leukaemia

  • Leukaemia Myelogenous

  • Leukemia Myelogenous

  • Myeloid Granulocytic Leukaemia

  • Myeloid Granulocytic Leukemia

  • Non-Lymphocytic Leukemia

  • Leukemia, Myeloid

  • Granulocytic Leukaemia

  • Myelogenous Leukaemia

  • Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Croup

  • Acute Obstructive Laryngitis

  • Laryngotracheobronchitis

  • Acute Laryngotracheobronchitis

  • Croup Syndrome

  • Acute Laryngitis With Obstruction

  • Obstructive Laryngitis

  • Obstructive Laryngitis Nos

  • Obstructive Laryngotracheitis Nos
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-101870B Uzansertib phosphate Inhibitor 99.77% Phase 2
HY-101870 Uzansertib Inhibitor 99.45% Phase 2
HY-15604 AZD1208 Inhibitor 99.73% Phase 1
HY-19322 PIM447 Inhibitor 99.52% Phase 1
HY-15698 CRT0066101 Inhibitor 99.88% Phase 1
HY-19322B PIM-447 dihydrochloride Inhibitor 99.82% Phase 1
HY-15604A AZD1208 hydrochloride Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15698A CRT0066101 dihydrochloride Inhibitor 99.97% Unkown
HY-16576A SMI-4a Inhibitor 99.85% Unkown
HY-N4149 Quercetagetin Inhibitor 99.94% Unkown
HY-16976 GDC-0339 Inhibitor 99.87% Unkown
HY-101947 SMI-16a Inhibitor 98.0% Unkown
HY-120758 SEL24-B489 Inhibitor 99.02% Unkown
HY-115590 JP-11646 Inhibitor 98.74% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.83% Unkown
HY-164460 AZD1897 Inhibitor 99.69% Unkown
HY-123983 HS56 Inhibitor 99.6% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-15698B CRT0066101 trihydrochloride Inhibitor / Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-181925 FD2024 Inhibitor / Unkown
HY-163442A PIM3-IN-1 hydrochloride Inhibitor / Unkown
HY-160006 PIM-IN-2 / Unkown
HY-186146 SGI-1776-VHL-02 Degrader 96.67% Unkown
HY-122670 VS-II-173 Inhibitor / Unkown
HY-168479 VB1080 Inhibitor / Unkown
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / Unkown
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PIM2 MGD MGI:97587
Canis familiaris PIM2 VGNC VGNC:44565
Felis catus PIM2 VGNC VGNC:68861
Bos taurus PIM2 VGNC VGNC:32900
Rattus norvegicus PIM2 RGD RGD:1560759
Others PIM2 NCBI