PIM3-IN-1 hydrochloride
PIM3-IN-1 hydrochloride (Compound 19a) is an inhibitor of (PIM2/3), with the highest inhibition level being against PIM3, having an IC50 value in the nanomolar range. PIM3-IN-1 hydrochloride can be used in cancer research.
For research use only. We do not sell to patients.
- Formula: C23H23Cl2N5
- Molecular Weight:440.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
PIM2 |
PIM3 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| H9c2 | EC50 |
5.3 μM
Compound: 19a
|
Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against rat H9c2 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
|
[PMID: 38537512] |
| MOLM-13 | EC50 |
0.21 μM
Compound: 19a
|
Cytotoxicity against human MOLM-13 cells assessed as induction of cell death incubated for 24 hrs by WST-1 assay
Cytotoxicity against human MOLM-13 cells assessed as induction of cell death incubated for 24 hrs by WST-1 assay
|
[PMID: 38537512] |
| MV4-11 | EC50 |
0.45 μM
Compound: 19a
|
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
|
[PMID: 38537512] |
| NRK | EC50 |
4 μM
Compound: 19a
|
Cytotoxicity against rat NRK cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against rat NRK cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
|
[PMID: 38537512] |
| OCI-AML-3 | EC50 |
0.64 μM
Compound: 19a
|
Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 24 hrs by WST-1 assay
|
[PMID: 38537512] |
Chemical Information
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Molecular Weight 440.37
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Formula C23H23Cl2N5
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SMILES
CNCCCN1C2=CC=CC=C2C3=C1C4=C(C5=C3C=NN5)C6=C(N4)C=CC=C6.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)