Ro 48-8587
Ro 48-8587 is a selective AMPA receptor antagonist with an IC50 of 8 nM. Ro 48-8587 functionally inhibits AMPA receptor activity, blocks AMPA-induced depolarization of rat cortical wedges. Ro 48-8587 can be used for the research of ischaemia and seizures.
For research use only. We do not sell to patients.
- CAS No.: 211120-62-6
- Formula: C12H7N7O4
- Molecular Weight:313.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All iGluR Isoforms
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Biological Activity
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AMPA Receptor 8 nM (IC50) |
Ro 48-8587 (1-2 h) potently inhibits [3H]AMPA, [3H]kainate and [3H]MK-801 binding to rat whole brain membranes with Ki values of 0.008, 1.3 and 8 μM[1].
Ro 48-8587 (1-10 μM) potently, competitively inhibits S-AMPA-induced depolarizations in rat brain cortical wedges with an IC50 of 0.089 μM[1].
Ro 48-8587 inhibits NMDA-induced depolarizations in rat brain cortical wedges with an IC50 of 4.4 μM[1].
Ro 48-8587 (0.5-50 nM; 1 h) binds to a single population of high-affinity sites on rat whole brain membranes with a KD of 3 ± 1 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ro 48-8587 7 prevents electroshock-induced convulsions or sound-induced seizures in MORO or DBA-2 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 211120-62-6
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Molecular Weight 313.23
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Formula C12H7N7O4
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SMILES
O=C1NN2C(NC3=C(C=C(N4C=CN=C4)C([N+]([O-])=O)=C3)C2=N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)