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Referencia número: HY-155111

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nSMase2-IN-1

Revisión del cliente

Based on 1 Customer Validation

nSMase2-IN-1 is an orally active Neutral sphingomyelinase 2 (nSMase2) inhibitor with an IC₅₀ value of 0.13 ± 0.06 μM. nSMase2-IN-1 is metabolically stable in liver microsomes and orally available with a favorable brain-to-plasma ratio. nSMase2-IN-1 can be used for nervous system disease research.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 98.05%
No. CAS: 2968322-24-7
Fòrmula: C₁₂H₁₇N₅O
Peso molecular:247.30

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

nSMase2-IN-1 Chemical Structure

No. CAS: 2968322-24-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
- In Vivo
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Phospholipase :

In Vitro

nSMase2-IN-1 (Compound 11j) (5μM, 60 min) shows excellent metabolic stability in rat liver microsomes with >95% remaining after 1 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

nSMase2-IN-1 (Compound 11j) (10 mg/kg for oral gavage, detection time of 30min, 2 h) is orally available and brain-penetrant in male Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats (Pharmacokinetic assay)^[1]
Dosage:

10 mg/kg
Administration:

Oral gavage (p.o.)
Result:

Absorbed quickly resulting in plasma concentration of more than 2 μM and had higher brain levels than plasma at 0.5 h.

Chemical Information

No. CAS 2968322-24-7
Appearance Solid
Peso molecular 247.30
Fòrmula C₁₂H₁₇N₅O
Color Light yellow to yellow
SMILES

CN(C1=C2N(C=CC(N3CCOCC3)=N2)N=C1)C
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Novotna K, et al. Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold. Eur J Med Chem. 2023 Nov 5;259:115674. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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nSMase2-IN-1

Bioactive Compound Library Max

Bioactive Compound Library

Metabolism/Protease Compound Library

CNS-Penetrant Compound Library

Orally Active Compound Library

Lipid Metabolism Compound Library

Metabolic Enzyme Compound Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Ver todos los productos específicos de isoformas Phospholipase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

nSMase2-IN-1

Bioactive Compound Library Max

Bioactive Compound Library

Metabolism/Protease Compound Library

CNS-Penetrant Compound Library

Orally Active Compound Library

Lipid Metabolism Compound Library

Metabolic Enzyme Compound Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Ver todos los productos específicos de isoformas Phospholipase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

nSMase2-IN-1 Related Classifications

HY-155111 Related Classifications