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Cat. No.: HY-P10994

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Eps8 peptide 327

(Synonyms: Eps8(327-335))

Eps8 peptide 327 is an HLA-A*2402-restricted peptide antigen derived from Eps8 protein. Eps8 peptide 327 has potent antitumor activity with significant cytotoxicity. Eps8 peptide 327 effectively inhibits cancer cells proliferation, induces apoptosis and disrupts EGFR signal pathway by inhibiting downstream signals (such as IL-2, TNF-α and IFN-γ) expression and the Eps8/EGFR interaction. Eps8 peptide 327 significantly inhibits tumor growth in HT-29 xenograft mcie models.

For research use only. We do not sell to patients.

CAS No.: 1988684-26-9
Formula: C₅₆H₇₇N₁₁O₁₅S
Molecular Weight:1176.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Eps8 peptide 327 Chemical Structure

CAS No.: 1988684-26-9

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- Sequence
- Sequence Shortening
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IL-2

All EGFR Isoforms :

All Interleukin Related Isoforms :

All TNF Receptor Isoforms :

Sequence

Glu-Phe-Leu-Asp-Cys-Phe-Gln-Lys-Phe

Sequence Shortening

EFLDCFQKF

Chemical Information

CAS No. 1988684-26-9
Molecular Weight 1176.34
Formula C₅₆H₇₇N₁₁O₁₅S
Synonyms

Eps8(327-335)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xie X, et al. A dual-function epidermal growth factor receptor pathway substrate 8 (Eps8)-derived peptide exhibits a potent cytotoxic T lymphocyte-activating effect and a specific inhibitory activity. Cell Death Dis. 2018 Mar 7;9(3):379. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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Biological Activity
- Description
- IC50 & Target
- Sequence
- Sequence Shortening
Chemical Information
Purity & Documentation
References

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Eps8 peptide 327

All EGFR Isoforms

All Interleukin Related Isoforms

All TNF Receptor Isoforms