VSNL1 - visinin like 1 Gene

Also Known as HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7447

About VSNL1

Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,539,972-17,657,018 (from NCBI)

This gene has 6 transcripts (splice variants), 263 orthologues and 14 paralogues. Biased expression in brain (RPKM 206.9), esophagus (RPKM 16.5) and 2 other tissues.

Summary

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

VSNL1 Products (5)

mRNA Protein Name
NM_001366803.2 NP_001353732.1 visinin-like protein 1 isoform 1
NM_001366804.2 NP_001353733.1 visinin-like protein 1 isoform 2
NM_001366805.2 NP_001353734.1 visinin-like protein 1 isoform 3
NM_001366806.2 NP_001353735.1 visinin-like protein 1 isoform 1
NM_003385.5 NP_003376.2 visinin-like protein 1 isoform 1
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VSNL1 Protein Structure

EF-hand_1

EF-hand_1: EF hand (66 - 90)

EF-hand_7

EF-hand_7: EF-hand domain pair (101 - 174)

  • 0
  • 100
  • 191 a.a.
Protein Preferred Names Protein Names

visinin-like protein 1

  • VLP-1

VSNL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VSNL1 P62760 TEX13B Homo sapiens Q9BXU2 32296183
Intra
VSNL1 P62760 TEX13B Homo sapiens Q9BXU2 32296183
Intra
VSNL1 P62760 TEX13B Homo sapiens Q9BXU2 32296183
Intra
VSNL1 P62760 SPRY3 Homo sapiens O43610 32296183
Intra
VSNL1 P62760 SPRY3 Homo sapiens O43610 32296183
Intra
VSNL1 P62760 SRL Homo sapiens Q86TD4-2 32296183
Intra
VSNL1 P62760 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8 32296183
Intra
VSNL1 P62760 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8 32296183
Intra
VSNL1 P62760 COL10A1 Homo sapiens Q03692 32296183
Intra
VSNL1 P62760 C1QTNF2 Homo sapiens Q9BXJ5 32296183
Intra
VSNL1 P62760 C1QTNF2 Homo sapiens Q9BXJ5 32296183
Intra
VSNL1 P62760 C1QTNF2 Homo sapiens Q9BXJ5 32296183
Intra
VSNL1 P62760 SPRED1 Homo sapiens Q7Z699 32296183
Intra
VSNL1 P62760 SPRED1 Homo sapiens Q7Z699 32296183
Intra
VSNL1 P62760 SPRED1 Homo sapiens Q7Z699 32296183
Intra
VSNL1 P62760 SPRED2 Homo sapiens Q7Z698 32296183
Intra
VSNL1 P62760 LITAF Homo sapiens Q99732 32296183
Intra
VSNL1 P62760 DTX2 Homo sapiens Q86UW9 32296183
Intra
VSNL1 P62760 DTX2 Homo sapiens Q86UW9 25416956
Intra
VSNL1 P62760 DTX2 Homo sapiens Q86UW9 32296183
Intra
VSNL1 P62760 DTX2 Homo sapiens Q86UW9 25416956
Intra
VSNL1 P62760 DTX2 Homo sapiens Q86UW9 16189514
Intra
VSNL1 P62760 DTX2 Homo sapiens Q86UW9 32296183
Intra
VSNL1 P62760 FAM131C Homo sapiens Q96AQ9 16189514
Intra
VSNL1 P62760 FAM131C Homo sapiens Q96AQ9 32296183
Intra
VSNL1 P62760 FAM131C Homo sapiens Q96AQ9 32296183
Intra
VSNL1 P62760 FAM131C Homo sapiens Q96AQ9 32296183
Intra
VSNL1 P62760 TFF1 Homo sapiens P04155 32296183
Intra
VSNL1 P62760 TFF1 Homo sapiens P04155 32296183
Intra
VSNL1 P62760 ATXN1 Homo sapiens P54253
Y2H
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VSNL1 Proteins

Cat. No. Product Name Accession Purity
HY-P71427 VSNL1 Protein, Human (His) P62760 (M1-K191) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76694 VSNL1 Protein, Human P62760 (G2-K191) ≥ 95%, as determined by reducing SDS-PAGE.

VSNL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87142 VILIP1 Antibody (YA6835) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Abcd Syndrome
  • ABCDS

  • Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut, And Deafness

  • Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut And Deafness

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Dementia, Lewy Body
  • Lewy Body Dementia

  • Lewy Body Disease

  • Diffuse Lewy Body Disease

  • Dementia With Lewy Bodies

  • DLB

  • Autosomal Dominant Diffuse Lewy Body Disease

  • Cortical Lewy Body Disease

  • Dementia, Lewy Body, Susceptibility To

  • Lewy Body Dementia, Susceptibility To

  • Senile Dementia Of The Lewy Body Type

  • Dementia Of The Lewy Body Type

  • Lbd

  • Diffuse Lewy Body Disease With Gaze Palsy

  • Dysphasic Dementia Hereditary

  • Lewy Body Type Senile Dementia

  • Lewy Body Variant Of Alzheimer Disease

  • Lewy Bodies

  • Lewy Body

  • Dlbd - [Diffuse Lewy Body Disease]

  • Clbd - [Cortical Lewy Body Disease]

Schizophrenia
  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus VSNL1 VGNC VGNC:36841
Felis catus VSNL1 VGNC VGNC:66981
Macaca mulatta VSNL1 VGNC VGNC:106244
Mus musculus VSNL1 MGD MGI:1349453
Rattus norvegicus VSNL1 RGD RGD:3966
Others VSNL1 NCBI