Referencia número: HY-100654

10-DEBC hydrochloride

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Based on 1 Customer Validation

10-DEBC hydrochloride is a selective Akt inhibitor, with an IC₅₀ of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza: 99.82%
No. CAS: 925681-41-0
Fòrmula: C₂₀H₂₆Cl₂N₂O
Peso molecular:381.34

Almacenamiento:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

10-DEBC hydrochloride Chemical Structure

No. CAS: 925681-41-0

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

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Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

10-DEBC hydrochloride is a selective Akt inhibitor, with an IC₅₀ of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound^[1]^[2].

Ver todos los productos específicos de isoformas Akt :

In Vitro

10-DEBC is found to inhibit the growth of Mtb in whole-cell assay with an IC₅₀ of 12.8 μM, while inhibiting replication of Mtb inside iMACs with an IC₅₀ of 1.5 μM, without host cell toxicity even at the highest concentration of 25 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 925681-41-0
Appearance Solid
Peso molecular 381.34
Fòrmula C₂₀H₂₆Cl₂N₂O
Color White to off-white
SMILES

CCN(CC)CCCCN1C2=C(C=CC=C2)OC3=CC=C(Cl)C=C13.[H]Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (262.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (131.12 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.6223 mL

13.1117 mL

26.2233 mL

5 mM

0.5245 mL

2.6223 mL

5.2447 mL

10 mM

0.2622 mL

1.3112 mL

2.6223 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wei Li, et al. More than just a GPCR ligand: structure-based discovery of thioridazine derivatives as Pim-1 kinase inhibitors. Medicinal Chemistry Communications.

[2]. Hyo-Won Han, et al. Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. Stem Cell Reports. 2019 Dec 10;13(6):980-991. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.6223 mL	13.1117 mL	26.2233 mL	65.5583 mL
	5 mM	0.5245 mL	2.6223 mL	5.2447 mL	13.1117 mL
	10 mM	0.2622 mL	1.3112 mL	2.6223 mL	6.5558 mL
	15 mM	0.1748 mL	0.8741 mL	1.7482 mL	4.3706 mL
	20 mM	0.1311 mL	0.6556 mL	1.3112 mL	3.2779 mL
	25 mM	0.1049 mL	0.5245 mL	1.0489 mL	2.6223 mL
	30 mM	0.0874 mL	0.4371 mL	0.8741 mL	2.1853 mL
	40 mM	0.0656 mL	0.3278 mL	0.6556 mL	1.6390 mL
	50 mM	0.0524 mL	0.2622 mL	0.5245 mL	1.3112 mL
	60 mM	0.0437 mL	0.2185 mL	0.4371 mL	1.0926 mL
	80 mM	0.0328 mL	0.1639 mL	0.3278 mL	0.8195 mL
	100 mM	0.0262 mL	0.1311 mL	0.2622 mL	0.6556 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

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10-DEBC hydrochloride

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Ver todos los productos específicos de isoformas Akt

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

10-DEBC hydrochloride Related Classifications

HY-100654 Related Classifications