Ifenprodil tartrate
Based on 10 publication(s) in Google Scholar
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM). Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC50 of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease.
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- Pureza: 99.94%
- No. CAS: 23210-58-4
- Fòrmula: C21H27NO2.1/2C4H6O6
- Peso molecular:400.49
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Ifenprodil tartrate
More- Chemosphere. 2019 Aug:229:618-630. [Abstract]
- Cell Rep. 2025 May 14;44(5):115712. [Abstract]
- Neurosci Bull. 2020 Feb;36(2):153-164. [Abstract]
- Life Sci. 2022 Apr 15:295:120419. [Abstract]
- Pharmaceuticals (Basel). 2024 Sep 19;17(9):1234. [Abstract]
- Eur J Pharmacol. 2024 Jul 25:176860. [Abstract]
- Eur J Pharmacol. 2023 Dec 15:961:176174. [Abstract]
- Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0103524. [Abstract]
- Heliyon. 2023 May 29;9(6):e16631. [Abstract]
- Exp Brain Res. 2023 Dec;241(11-12):2735-2750. [Abstract]
Ver todos los productos específicos de isoformas iGluR
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Actividad biológica
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NMDA Receptor |
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Cell Line
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Type | Value | Description | References |
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| Cortical neurone | IC50 |
3.5 μM
Compound: 10
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Neuroprotective activity in rat Cortical neuron assessed as protection from glutamate-induced neurotoxicity treated after glutamate-challenge by lactate dehydrogenase assay
Neuroprotective activity in rat Cortical neuron assessed as protection from glutamate-induced neurotoxicity treated after glutamate-challenge by lactate dehydrogenase assay
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[PMID: 23458846] |
| Oocyte | IC50 |
0.073 μM
Compound: ifenprodil
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Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method
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[PMID: 18800760] |
| Oocyte | IC50 |
0.19 μM
Compound: 1
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Antagonist activity at wild type NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of agonist-induced current amplitude by two-electrode voltage-clamp method
Antagonist activity at wild type NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of agonist-induced current amplitude by two-electrode voltage-clamp method
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[PMID: 20692832] |
| Oocyte | IC50 |
0.34 μM
Compound: 10
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Inhibition of GluN1/GluN2B receptor (unknown origin) expressed in Xenopus oocytes by voltage clamp assay
Inhibition of GluN1/GluN2B receptor (unknown origin) expressed in Xenopus oocytes by voltage clamp assay
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[PMID: 23458846] |
| SH-SY5Y | IC50 |
0.73 nM
Compound: ifenprodil
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Neuroprotective activity in human SH-SY5Y cells assessed as protection against NMDA-induced cell death after 6 hrs by MTS assay
Neuroprotective activity in human SH-SY5Y cells assessed as protection against NMDA-induced cell death after 6 hrs by MTS assay
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[PMID: 23033965] |
The degree of inhibition seen with 100 μM Ifenprodil tartrate at NR1A/NR2A receptors is not altered by changes in the concentration of extracellular glycine. However, the inhibitory effect of 1 μM Ifenprodil tartrate at NR1A/NR2B receptors is reduced by increasing the concentration of glycine[1].
In oocytes injected with mRNAs for GIRK1/GIRK2, GIRK2 or GIRK1/GIRK4 subunits, Ifenprodil (3 μM) tartrate reversibly reduces inward currents through the basal GIRK activity[2].
Ifenprodil tartrate interacts with several other receptors, namely, serotonin (5-HT) subtype 1A, 5-HT2 and 5-HT3 receptors, and σ receptors at nanomolar concentrations and that it inhibits voltage-gated Ca2+ channels at micromolar concentrations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (300-350 g)[3]
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Dosage:0.25, 0.36, 0.68, 0.90, and 1.13 μmol (50 μL)
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Administration:Intrathecal injection; once
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Result:Produced spinal blockades of motor function and nociception dose-dependently.
Chemical Information
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No. CAS 23210-58-4
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Appearance Solid
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Peso molecular 400.49
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Fòrmula C21H27NO2.1/2C4H6O6
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Color White to off-white
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SMILES
OC(C1=CC=C(O)C=C1)C(C)N(CC2)CCC2CC3=CC=CC=C3.O=C(O)[C@H](O)[C@@H](O)C(O)=O.[1/2]
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Synonyms
NP-120 tartrate; RC-61-91 tartrate
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (10)
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Journal Impact Factor
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Most Recent
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Chemosphere
Bisphenol-A induces neurodegeneration through disturbance of intracellular calcium homeostasis in human embryonic stem cells-derived cortical neurons. [Abstract]2019 Aug:229:618-630. PMID: 31102917 -
Cell Rep
Septo-subicular cholinergic circuit promotes seizure development via astrocytic inflammation. [Abstract]2025 May 14;44(5):115712. PMID: 40372911 -
Neurosci Bull
2020 Feb;36(2):153-164. PMID: 31444653 -
Life Sci
EphrinB2/ephB2 activation facilitates colonic synaptic potentiation and plasticity contributing to long-term visceral hypersensitivity in irritable bowel syndrome. [Abstract]2022 Apr 15:295:120419. PMID: 35183555 -
Pharmaceuticals (Basel)
2024 Sep 19;17(9):1234. PMID: 39338396 -
Eur J Pharmacol
Efficacy of GluN2B-Containing NMDA receptor antagonist for antitumor and antidepressant therapy in non-small cell lung cancer. [Abstract]2024 Jul 25:176860. PMID: 39067562 -
Eur J Pharmacol
A novel dopamine D2 receptor-NR2B protein complex might contribute to morphine use disorders. [Abstract]2023 Dec 15:961:176174. PMID: 37939993 -
Antimicrob Agents Chemother
2024 Nov 6;68(11):e0103524. PMID: 39360823 -
Heliyon
Mechanism of new optimized Sheng-Mai-San Formula to regulate cardiomyocyte apoptosis through NMDAR pathway. [Abstract]2023 May 29;9(6):e16631. PMID: 37416647 -
Exp Brain Res
The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults. [Abstract]2023 Dec;241(11-12):2735-2750. PMID: 37845379
Solvente y solubilidad
DMSO : ≥ 500 mg/mL (1248.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (12.48 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 1% DMSO 99% Saline
Solubility: ≥ 1 mg/mL (2.50 mM); Clear solution
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 12.22 mg/mL (30.51 mM); Suspended solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Williams K, et al. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol. 1993 Oct;44(4):851-9. [Content Brief]
[2]. Kobayashi T, et al. Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. Neuropsychopharmacology. 2006 Mar;31(3):516-24. [Content Brief]
[3]. Chen YW, et al. Ifenprodil for prolonged spinal blockades of motor function and nociception in rats. Pharmacol Rep. 2016 Apr;68(2):357-62. [Content Brief]
[4]. Jang Y, et al. In Vitro and In Vivo Antiviral Activity of Nylidrin by Targeting the Hemagglutinin 2-Mediated Membrane Fusion of Influenza A Virus. Viruses. 2020 May 25;12(5):581. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.4969 mL | 12.4847 mL | 24.9694 mL | 62.4235 mL |
| 5 mM | 0.4994 mL | 2.4969 mL | 4.9939 mL | 12.4847 mL | |
| 10 mM | 0.2497 mL | 1.2485 mL | 2.4969 mL | 6.2424 mL | |
| DMSO | 15 mM | 0.1665 mL | 0.8323 mL | 1.6646 mL | 4.1616 mL |
| 20 mM | 0.1248 mL | 0.6242 mL | 1.2485 mL | 3.1212 mL | |
| 25 mM | 0.0999 mL | 0.4994 mL | 0.9988 mL | 2.4969 mL | |
| 30 mM | 0.0832 mL | 0.4162 mL | 0.8323 mL | 2.0808 mL | |
| 40 mM | 0.0624 mL | 0.3121 mL | 0.6242 mL | 1.5606 mL | |
| 50 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2485 mL | |
| 60 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0404 mL | |
| 80 mM | 0.0312 mL | 0.1561 mL | 0.3121 mL | 0.7803 mL | |
| 100 mM | 0.0250 mL | 0.1248 mL | 0.2497 mL | 0.6242 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ifenprodil tartrate Related Classifications
Referencia número: HY-12882A
Powered by Bioz
- Ifenprodil
- 23210-58-4
- NP-120
- RC-61-91
- NP120
- NP 120
- iGluR
- Adrenergic Receptor
- Potassium Channel
- Calcium Channel
- Influenza Virus
- α1 adrenergic receptor
- NMDA receptor antagonist
- cerebral vasodilator
- GIRK
- Kir3
- neuroprotective
- anticonvulsant and antinociceptive effects
- cerebrovascular diseases
- peripheral arterial obliterative disease
- Inhibitor
- inhibitor
- inhibit