Anaplastic lymphoma kinase (ALK) Ligand

ALK ligand-2 (compound 3) is a ALK ligand that can be used to synthesize PROTAC degraders targeting ALK (HY-122582). ALK ligand-2 is applicable to research related to non-small cell lung cancer, anaplastic large cell lymphoma, and neuroblastoma.

DGKα-IN-2 (example 48) is a DGKα inhibitor with the IC₅₀ of 0.9 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.

ALK protein ligand-1-PEG2-N3 is an ALK ligand intermediate with a PEG2 linker, which can be used to synthesize ALK-targeting PROTAC degraders (HY-122582). ALK protein ligand-1-PEG2-N3 is applicable to research related to non-small cell lung cancer, anaplastic large cell lymphoma, and neuroblastoma.

Brigatinib A is an GID4 ligand. Brigatinib A can be used for synthesizing PROTAC BCR-ABL Degrader-2 (HY-174368).

ALK5 ligand-1 (a31's ALK5 ligand) is a ligand of Anaplastic lymphoma kinase ALK5 with higher selectivity for ALK5 than for ALK4. ALK5 ligand-1 can be used to synthesize PROTAC degraders targeting ALK5. ALK5 PROTACs induce ALK5 degradation dependent on the ubiquitin-proteasome system and exert antifibrotic activity. ALK5 ligand-1 can be used in studies of pulmonary fibrosis.

Ceritinib-amide-C3-acid is a target protein ligand-linker conjugate. Ceritinib-amide-C3-acid incorporates a protein ligand Ceritinib (HY-15656) and a link for E3 ligases ligand. Ceritinib-amide-C3-acid can be used for the synthesis of TD-004 (HY-180970).

ALK ligand-1 is a ALK ligand that can be used for synthesis of PROTAC ALK degrader-4 (HY-175527).

ALK5 ligand-1-amine-C2-piperazine-C4-OH is a conjugate of a ligand targeting ALK5 and a PROTAC linker. ALK5 ligand-1-amine-C2-piperazine-C4-OH can be used to synthesize the PROTAC degrader (a31). ALK5 PROTACs induce UPS-dependent and selective degradation of ALK5 over ALK4. ALK5 ligand-1-amine-C2-piperazine-C4-OH can be applied to research on pulmonary fibrosis.