ALK5 ligand-1
ALK5 ligand-1 (a31's ALK5 ligand) is a ligand of Anaplastic lymphoma kinase ALK5 with higher selectivity for ALK5 than for ALK4. ALK5 ligand-1 can be used to synthesize PROTAC degraders targeting ALK5. ALK5 PROTACs induce ALK5 degradation dependent on the ubiquitin-proteasome system and exert antifibrotic activity. ALK5 ligand-1 can be used in studies of pulmonary fibrosis.
For research use only. We do not sell to patients.
- CAS No.: 3125240-66-3
- Formula: C20H14ClFN4O3
- Molecular Weight:412.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Chemical Information
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CAS No. 3125240-66-3
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Molecular Weight 412.80
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Formula C20H14ClFN4O3
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SMILES
ClC1=CC(C2=CC(N3C4=CC=NC=C4N(CC(O)=O)C3=O)=C(C)C=N2)=C(F)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)