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Cat. No.: HY-183441

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ALK5 ligand-1

ALK5 ligand-1 (a31's ALK5 ligand) is a ligand of Anaplastic lymphoma kinase ALK5 with higher selectivity for ALK5 than for ALK4. ALK5 ligand-1 can be used to synthesize PROTAC degraders targeting ALK5. ALK5 PROTACs induce ALK5 degradation dependent on the ubiquitin-proteasome system and exert antifibrotic activity. ALK5 ligand-1 can be used in studies of pulmonary fibrosis.

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CAS No.: 3125240-66-3
Formule: C₂₀H₁₄ClFN₄O₃
Masse moléculaire:412.80

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Please store the product under the recommended conditions in the Certificate of Analysis.

ALK5 ligand-1 Chemical Structure

CAS No.: 3125240-66-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Chemical Information

CAS No. 3125240-66-3
Masse moléculaire 412.80
Formule C₂₀H₁₄ClFN₄O₃
SMILES

ClC1=CC(C2=CC(N3C4=CC=NC=C4N(CC(O)=O)C3=O)=C(C)C=N2)=C(F)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Yue L, et al. Design, synthesis, and biological evaluation of ALK5 PROTAC degraders for pulmonary fibrosis. Bioorg Chem. 2026;178:109945. [Content Brief]

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100 mg

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