Brigatinib A
Brigatinib A is an GID4 ligand. Brigatinib A can be used for synthesizing PROTAC BCR-ABL Degrader-2 (HY-174368).
For research use only. We do not sell to patients.
- CAS No.: 1197958-90-9
- Formula: C23H28ClN6O2P
- Molecular Weight:486.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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EML4-ALK |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H1975 | IC50 |
0.88 μM
Compound: BA
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Inhibition of cell viability in human NCI-H1975 cells incubated for 48 to 72 hrs by CCK8 assay
Inhibition of cell viability in human NCI-H1975 cells incubated for 48 to 72 hrs by CCK8 assay
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[PMID: 39114932] |
| NCI-H3122 | IC50 |
0.3 μM
Compound: BA
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Inhibition of cell viability in human NCI-H3122 cells incubated for 48 to 72 hrs by CCK8 assay
Inhibition of cell viability in human NCI-H3122 cells incubated for 48 to 72 hrs by CCK8 assay
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[PMID: 39114932] |
| SR | IC50 |
1.6 nM
Compound: 1
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Antiproliferative activity against human SR cells assessed as reduction in cell growth
Antiproliferative activity against human SR cells assessed as reduction in cell growth
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[PMID: 32179332] |
Chemical Information
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CAS No. 1197958-90-9
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Molecular Weight 486.93
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Formula C23H28ClN6O2P
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SMILES
COC1=CC(N2CCNCC2)=CC=C1NC3=NC=C(C(NC4=CC=CC=C4P(C)(C)=O)=N3)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Brigatinib A Related Classifications
HY-150908 Related Classifications
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