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Referencia número: HY-19881

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ABT-288

ABT-288 is a competitive, potent and selective histamine H3 receptor (H3R) antagonist. ABT-288 has K_i values of 1.9 and 8.2 nM for human and rat H3Rs, respectively. ABT-288 can be used in cognitive impairment research..

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No. CAS: 948845-91-8
Fòrmula: C₂₃H₂₄N₄O
Peso molecular:372.46

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ABT-288 Chemical Structure

No. CAS: 948845-91-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

IC₅₀ & Target

human H₃ receptor

1.9 nM (Ki)

rat H₃ receptor

8.2 nM (Ki)

Ver todos los productos específicos de isoformas Histamine Receptor :

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 948845-91-8
Peso molecular 372.46
Fòrmula C₂₃H₂₄N₄O
SMILES

CN1C[C@]2([H])N(C3=CC=C(C4=CC=C(N5C(C=CC=N5)=O)C=C4)C=C3)CC[C@]2([H])C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Esbenshade TA, et al. Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist. J Pharmacol Exp Ther. 2012 Oct;343(1):233-45. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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ABT-288

Ver todos los productos específicos de isoformas Histamine Receptor

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

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ABT-288 Related Classifications

HY-19881 Related Classifications