AGL 2043
AGL 2043 is an effective inhibitor of PDGFR (IC50=0.8 μM) and TEL-PDGFR kinases, as well as FLT3 and KIT kinases. AGL 2043 can effectively inhibit porcine cardiac smooth muscle cell proliferation and balloon-induced vascular stenosis, and is suitable for development as an anti-restenotic and anticancer agent.
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- No. CAS: 226717-28-8
- Fòrmula: C15H12N4S
- Peso molecular:280.35
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Actividad biológica
IC50: 0.8 μM (PDGFR)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
1 μM
Compound: 27; AGL 2043
|
Inhibition of human FLT3 expressed in mouse BAF3 cells assessed as reduction in tyrphostin activity incubated for 2 hrs followed by FLT3 ligand stimulation by immunoblot analysis
Inhibition of human FLT3 expressed in mouse BAF3 cells assessed as reduction in tyrphostin activity incubated for 2 hrs followed by FLT3 ligand stimulation by immunoblot analysis
|
[PMID: 30502116] |
| NIH3T3 | IC50 |
>30 μM
Compound: 27; AGL 2043
|
Inhibition of SRC in transformed mouse NIH3T3 cells by SDS-PAGE based immunoblot assay
Inhibition of SRC in transformed mouse NIH3T3 cells by SDS-PAGE based immunoblot assay
|
[PMID: 30502116] |
Chemical Information
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No. CAS 226717-28-8
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Peso molecular 280.35
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Fòrmula C15H12N4S
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SMILES
CC(N1C)=NC2=C1C=C3N=CC(C4=CC=CS4)=NC3=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)