Aloesin
Based on 1 publication(s) in Google Scholar
Aloesin (Aloeresin) is a tyrosinase inhibitor, and shows anti-inflammatory activity, ultraviolet protection, and antibacterium effects. Aloesin can induce apoptosis and be used in ovarian cancer research.
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- Pureza: 99.62%
- No. CAS: 30861-27-9
- Fòrmula: C19H22O9
- Peso molecular:394.37
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Aloesin
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Actividad biológica
Aloesin (0-40 μM, 24, 48, and 72 h) inhibits ovarian cancer cell growth in a dose- and time-dependent manner[1].
Aloesin (0-10 μM; 48 h) arrest the cell cycle at S-phase in a dose-dependent manner in SKOV3 cells[1].
Aloesin (0-10 μM; 48 h) promotes cell apoptosis in SKOV3 cells[1].
Aloesin (0-10 μM; 48 h) inhibits the phosphorylation of the MAPK signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF10A, T47D, MCF7, MDA-MB-468, and MDA-MB-231 cells
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Concentration:0, 2.5, 5, 10, 20, and 40 μM
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Incubation Time:24, 48, and 72 h
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Result:Exhibited a concentration-dependent and time-dependent killing of diverse ovarian cancer cell lines.
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Cell Line:SKOV3 cells
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Concentration:2.5-10 μM
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Incubation Time:48 hours
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Result:Showed a significantly potent toxic effect with an IC50 value of around 5 μM.
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Cell Line:SKOV3 cells
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Concentration:0, 2.5, 5, and 10 μM
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Incubation Time:48 h
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Result:Decresed the percentage of cells in the G2/M phase gradually with increasing doses, increased the percentages of cells in the S-phase.
Downregulated the levels of the S-G2/M-related proteins cyclin A, CDK2, and cyclin D1.
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Cell Line:SKOV3 cells
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Concentration:0, 2.5, 5, and 10 μM
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Incubation Time:48 h
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Result:Detected significant proteolytic cleavage of caspase-3, caspase-9, and PARP1.
Increased the expression of Bax and conversely decreased Bcl-2.
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Cell Line:SKOV3 cells
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Concentration:0, 2.5, 5, and 10 μM
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Incubation Time:48 h
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Result:Decreased phosphorylated levels of MEK, ERK, MAPK, and JNK.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old athymic nude mice injected with SKOV3 cells
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Dosage:20 mg/kg or 40 mg/kg
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Administration:Injection; 20 mg/kg or 40 mg/kg; once daily; 7 weeks
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Result:Reduced volumes and average weights of dissected tumors significantly compared with the control group.
Chemical Information
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No. CAS 30861-27-9
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Appearance Solid
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Peso molecular 394.37
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Fòrmula C19H22O9
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Color White to off-white
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SMILES
OC1=CC(C)=C(C(C=C(CC(C)=O)O2)=O)C2=C1[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO
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Synonyms
Aloeresin
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvente y solubilidad
DMSO : 100 mg/mL (253.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.25 mg/mL (5.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.25 mg/mL (5.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (284 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zhang LQ, et al. Aloesin Suppresses Cell Growth and Metastasis in Ovarian Cancer SKOV3 Cells through the Inhibition of the MAPK Signaling Pathway. Anal Cell Pathol (Amst). 2017;2017:8158254. [Content Brief]
[2]. Wahedi HM, et al. Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. Phytomedicine. 2017 May 15;28:19-26. [Content Brief]
[3]. Y H Jin, et al. Aloesin and arbutin inhibit tyrosinase activity in a synergistic manner via a different action mechanism. Arch Pharm Res. 1999 Jun;22(3):232-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5357 mL | 12.6784 mL | 25.3569 mL | 63.3922 mL |
| 5 mM | 0.5071 mL | 2.5357 mL | 5.0714 mL | 12.6784 mL | |
| 10 mM | 0.2536 mL | 1.2678 mL | 2.5357 mL | 6.3392 mL | |
| 15 mM | 0.1690 mL | 0.8452 mL | 1.6905 mL | 4.2261 mL | |
| 20 mM | 0.1268 mL | 0.6339 mL | 1.2678 mL | 3.1696 mL | |
| 25 mM | 0.1014 mL | 0.5071 mL | 1.0143 mL | 2.5357 mL | |
| 30 mM | 0.0845 mL | 0.4226 mL | 0.8452 mL | 2.1131 mL | |
| 40 mM | 0.0634 mL | 0.3170 mL | 0.6339 mL | 1.5848 mL | |
| 50 mM | 0.0507 mL | 0.2536 mL | 0.5071 mL | 1.2678 mL | |
| 60 mM | 0.0423 mL | 0.2113 mL | 0.4226 mL | 1.0565 mL | |
| 80 mM | 0.0317 mL | 0.1585 mL | 0.3170 mL | 0.7924 mL | |
| 100 mM | 0.0254 mL | 0.1268 mL | 0.2536 mL | 0.6339 mL |
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