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Referencia número: HY-P4253

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Arginyl-Glutamine

(Synonyms: H-Arg-Gln-OH)

Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy.

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No. CAS: 2483-17-2
Fòrmula: C₁₁H₂₂N₆O₄
Peso molecular:302.33

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Arginyl-Glutamine Chemical Structure

No. CAS: 2483-17-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
- In Vivo
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Actividad biológica

Descripciòn

Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy^[1].

IC₅₀ & Target

VEGF^[1]

Ver todos los productos específicos de isoformas VEGFR :

In Vitro

Arginyl-Glutamine (0.5-1.5 mM; 48 h) results in a statistically significant dose-dependent decrease soluble VEGF expression into the culture medium in human RPE cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Arginyl-Glutamine (1-5 g/kg/day as a hydrochloride salt; i.p.; twice daily) dramatically inhibits retinal neovascularization in the mouse oxygen-induced retinopathy (OIR) model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL6/J mouse pups, oxygen-induced retinopathy (OIR) model^[1]
Dosage:

1.0, 2.5, or 5 g/kg per day
Administration:

Intraperitoneal injection, twice daily
Result:

Significantly decreased preretinal nuclei. Reduced neovascular tufts and vascular leakage in retinal vessels. Reduced preretinal neovascularization by 82% ± 7% and reduced VEGF mRNA by 64% ± 9% at 5 g/kg per day.

Chemical Information

No. CAS 2483-17-2
Peso molecular 302.33
Fòrmula C₁₁H₂₂N₆O₄
Synonyms

H-Arg-Gln-OH
Sequence

Arg-Gln
Sequence Shortening

RQ
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Neu J, et al. The dipeptide Arg-Gln inhibits retinal neovascularization in the mouse model of oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3151-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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- In Vivo
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Arginyl-Glutamine

High-Throughput Bioactive Compound Library

Ver todos los productos específicos de isoformas VEGFR

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Arginyl-Glutamine Related Classifications

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