AT-9010 tetrasodium
Based on 1 publication(s) in Google Scholar
AT-9010 tetrasodium, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 tetrasodium can inhibit SARS-CoV-2 replication.
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- Pureza: 99.88%
- No. CAS: 1621884-18-1
- Fòrmula: C11H13FN5Na4O13P3
- Peso molecular:627.13
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Almacenamiento:
-80°C, protect from light, stored under nitrogen
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AT-9010 tetrasodium
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Actividad biológica
NiRAN[1]
Substantial levels of the active triphosphate metabolite AT-9010 are formed in normal human bronchial and nasal epithelial cells incubated with 10 μM AT-511 (698 μM and 236 μM, respectively), with a half-life of at least 38 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1621884-18-1
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Appearance Solid
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Peso molecular 627.13
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Fòrmula C11H13FN5Na4O13P3
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Color White to off-white
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SMILES
O[C@H]1[C@](F)(C)[C@H](N2C3=C(C(N=C(N3)N)=O)N=C2)O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O
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Envío
Shipping with dry ice.
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Almacenamiento
-80°C, protect from light, stored under nitrogen
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors. [Abstract]2022 Nov 10;185(23):4347-4360.e17. PMID: 36335936
Solvente y solubilidad
H2O : 100 mg/mL (159.46 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (159.46 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.5946 mL | 7.9728 mL | 15.9457 mL | 39.8641 mL |
| 5 mM | 0.3189 mL | 1.5946 mL | 3.1891 mL | 7.9728 mL | |
| 10 mM | 0.1595 mL | 0.7973 mL | 1.5946 mL | 3.9864 mL | |
| 15 mM | 0.1063 mL | 0.5315 mL | 1.0630 mL | 2.6576 mL | |
| 20 mM | 0.0797 mL | 0.3986 mL | 0.7973 mL | 1.9932 mL | |
| 25 mM | 0.0638 mL | 0.3189 mL | 0.6378 mL | 1.5946 mL | |
| 30 mM | 0.0532 mL | 0.2658 mL | 0.5315 mL | 1.3288 mL | |
| 40 mM | 0.0399 mL | 0.1993 mL | 0.3986 mL | 0.9966 mL | |
| 50 mM | 0.0319 mL | 0.1595 mL | 0.3189 mL | 0.7973 mL | |
| 60 mM | 0.0266 mL | 0.1329 mL | 0.2658 mL | 0.6644 mL | |
| 80 mM | 0.0199 mL | 0.0997 mL | 0.1993 mL | 0.4983 mL | |
| 100 mM | 0.0159 mL | 0.0797 mL | 0.1595 mL | 0.3986 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
AT-9010 tetrasodium Related Classifications
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