1. Anti-infection
  2. SARS-CoV
  3. Merafloxacin

Merafloxacin (Synonyms: CI-934)

Cat. No.: HY-139010
Handling Instructions

Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria.

For research use only. We do not sell to patients.

Merafloxacin Chemical Structure

Merafloxacin Chemical Structure

CAS No. : 91188-00-0

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Description

Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2].

IC50 & Target

IC50: 19.6 μM (SARS-CoV-2)[1]

In Vitro

Merafloxacin (5-80 μM) dose-dependently inhibits programmed -1 ribosomal frameshifting (-1 PRF) of SARS-CoV-2, SARS-CoV, hCoVO-C43, and hCoV-HKU1, with IC50s of 19.6 μM, 19.5 μM, 29.7 μM, and 38.6 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

379.40

Formula

C₁₉H₂₃F₂N₃O₃

CAS No.
SMILES

O=C(C1=CN(CC)C2=C(C=C(F)C(N3CC(CNCC)CC3)=C2F)C1=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MerafloxacinCI-934CI934CI 934SARS-CoVSARS coronavirusfluoroquinoloneantibacterialprogrammed-1ribosomalframeshiftingPRFcoronavirusesgram-positivegram-negativebacteriaInhibitorinhibitorinhibit

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Merafloxacin
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HY-139010
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