1. Anti-infection
  2. SARS-CoV
  3. XP-59

XP-59 

Cat. No.: HY-136284 Purity: 98.42%
Handling Instructions

XP-59 is a potent inhibitor of the SARS-CoV Mpro, with a Ki of 0.1 μM.

For research use only. We do not sell to patients.

XP-59 Chemical Structure

XP-59 Chemical Structure

CAS No. : 890402-73-0

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Description

XP-59 is a potent inhibitor of the SARS-CoV Mpro, with a Ki of 0.1 μM[1].

IC50 & Target

Ki: 0.1 nM (SARS-CoV Mpro)[1].

In Vitro

The SARS-CoV main proteinase (Mpro) plays a central role in the formation of the viral replicase/transcriptase complex and is thus an ideal target for the development of suitable drugs[1].

Molecular Weight

282.30

Formula

C₁₅H₁₄N₄O₂

CAS No.

890402-73-0

SMILES

O=C(ON1N=NC2=CC=CC=C21)C3=CC=C(N(C)C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (221.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5423 mL 17.7117 mL 35.4233 mL
5 mM 0.7085 mL 3.5423 mL 7.0847 mL
10 mM 0.3542 mL 1.7712 mL 3.5423 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (22.14 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (22.14 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (22.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

XP-59XP59XP 59SARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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XP-59
Cat. No.:
HY-136284
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