Betulinaldehyde
Based on 5 publication(s) in Google Scholar
Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca2+/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research.
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- Pureza: 98.72%
- No. CAS: 13159-28-9
- Fòrmula: C30H48O2
- Peso molecular:440.70
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Betulinaldehyde
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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WB
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16 | ED50 |
3.3 μM
Compound: 9
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Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
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[PMID: 12027734] |
| B16 | IC50 |
6.4 μM
Compound: 9
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Growth inhibition of mouse B16 2F2 cells after 3 days
Growth inhibition of mouse B16 2F2 cells after 3 days
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[PMID: 12027734] |
| Epithelial cell | IC50 |
19.4 μM
Compound: betulinaldehyde
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Antiproliferative activity against mouse +SA mammary epithelial cells after 4 days by MTT assay
Antiproliferative activity against mouse +SA mammary epithelial cells after 4 days by MTT assay
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[PMID: 18826277] |
Betulinaldehyde (20, 40, 80 μM; 24 h) inhibits the colony formation ability of A549 cells in a concentration-dependent manner[3].
Betulinaldehyde (20 μM; 24 h) inhibits the phosphorylation of Akt, MAPK and STAT3 in A549 cells[3].
Betulinaldehyde (80 μM, 160 μM; 24 h) leads vascular remodeling in rats with carotid balloon injurys, and inhibits intracellular Ca2+ levels[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 13159-28-9
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Appearance Solid
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Peso molecular 440.70
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Fòrmula C30H48O2
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Color White to off-white
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SMILES
C=C(C)[C@@H]1CC[C@]2(C=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H]
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Synonyms
Betulinic aldehyde; Betunal
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Betulinaldehyde inhibits vascular remodeling by regulating the microenvironment through the PLCγ1/Ca2+/MMP9 pathway. [Abstract]2023 Jul 25:116:154891. PMID: 37229891 -
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Life Sci
Betulinaldehyde regulates VSMC phenotypic transition to alleviate vascular hyperplasia through PPARγ/mitochondria/ROS axis. [Abstract]2025 Nov 15:381:124002. PMID: 41033650 -
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Sci Rep
Betulinaldehyde exhibits effective anti-tumor effects in A549 cells by regulating intracellular autophagy. [Abstract]2023 Jan 13;13(1):743. PMID: 36639415
Betulinaldehyde purchased from MedChemExpress. Usage Cited in: Sci Rep. 2023 Jan 13;13(1):743. [Abstract]
Betulinaldehyde (20, 40, 80 μM; 24 h) significantly inhibits viability of A549 cells.
Betulinaldehyde purchased from MedChemExpress. Usage Cited in: Sci Rep. 2023 Jan 13;13(1):743. [Abstract]
The positive colony number of A549 cells is reduced by Betulinaldehyde concentrations of > 20 μM, while the colony formation ability of the A549 cells is almost completely inhibited when the concentration reaches 80 μM.
Betulinaldehyde purchased from MedChemExpress. Usage Cited in: Sci Rep. 2023 Jan 13;13(1):743. [Abstract]
Betulinaldehyde (20 μM) for 60 min, the phosphorylated Akt level is significantly inhibited, while the activity of the Akt signaling pathway is almost completely inhibited after 180 min.
Solvente y solubilidad
DMSO : 20 mg/mL (45.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2 mg/mL (4.54 mM); Clear solution
This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Chung PY, et al. Identification, by gene expression profiling analysis, of novel gene targets in Staphylococcus aureus treated with betulinaldehyde. Res Microbiol. 2013 May;164(4):319-26. [Content Brief]
[2]. Chung PY, et al. Transcriptional profiles of the response of methicillin-resistant Staphylococcus aureus to pentacyclic triterpenoids. PLoS One. 2013;8(2):e56687. [Content Brief]
[3]. Huang PH, et al. Betulinaldehyde exhibits effective anti-tumor effects in A549 cells by regulating intracellular autophagy. Sci Rep. 2023 Jan 13;13(1):743. [Content Brief]
[4]. Fu Y, et al. Betulinaldehyde inhibits vascular remodeling by regulating the microenvironment through the PLCγ1/Ca2+/MMP9 pathway. Phytomedicine. 2023 Jul 25;116:154891. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2691 mL | 11.3456 mL | 22.6912 mL | 56.7279 mL |
| 5 mM | 0.4538 mL | 2.2691 mL | 4.5382 mL | 11.3456 mL | |
| 10 mM | 0.2269 mL | 1.1346 mL | 2.2691 mL | 5.6728 mL | |
| 15 mM | 0.1513 mL | 0.7564 mL | 1.5127 mL | 3.7819 mL | |
| 20 mM | 0.1135 mL | 0.5673 mL | 1.1346 mL | 2.8364 mL | |
| 25 mM | 0.0908 mL | 0.4538 mL | 0.9076 mL | 2.2691 mL | |
| 30 mM | 0.0756 mL | 0.3782 mL | 0.7564 mL | 1.8909 mL | |
| 40 mM | 0.0567 mL | 0.2836 mL | 0.5673 mL | 1.4182 mL |
Betulinaldehyde Related Classifications
HY-N0084 Related Classifications
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