Chloramphenicol succinate
Based on 3 publication(s) in Google Scholar
Chloramphenicol succinate is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC50 of 1.585 nM. Chloramphenicol succinate serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate exerts a significant inhibitory effect on colitis. Chloramphenicol succinate can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease.
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- No. CAS: 3544-94-3
- Fòrmula: C15H16Cl2N2O8
- Peso molecular:423.20
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Chloramphenicol succinate
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Actividad biológica
Chloramphenicol succinate (50 μM; 3-24 h) is slowly oxidized to Chloramphenicol by cultured human bone marrow monocytes within 24 h[1].
Chloramphenicol succinate (50-100 μM; 30-60 min) is oxidized to Chloramphenicol by mitochondria isolated from human liver, rat liver and rat kidney within 60 min[1].
Chloramphenicol succinate is hydrolyzed by esterases present in the liver, kidney and lung of humans and animals, but not by blood esterases[2].
Chloramphenicol succinate ((0.01-100 μM; 24 h) exhibits only extremely low cytotoxicity against HT-29 cells when incubated at concentrations up to 100 μM for 24 h[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 J (male, 7-8-week-old, DSS-induced colitis)[3]
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Dosage:50 μM; 100 μM
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Administration:rectal; daily; 7 days
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Result:Significantly attenuated DSS-induced colitis symptoms.
Reduced weight loss.
Lowered Disease Activity Index (DAI) scores.
Prevented colon shortening.
Mitigated colon tissue damage and inflammatory cell infiltration.
Enhanced gut barrier integrity via increased expression of tight junction proteins (Claudin-1, Occludin, ZO-1).
Chemical Information
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No. CAS 3544-94-3
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Peso molecular 423.20
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Fòrmula C15H16Cl2N2O8
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SMILES
O=C(OC[C@@H](NC(C(Cl)Cl)=O)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)CCC(O)=O
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Structure Classification
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Initial Source
Streptomyces venequelae
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Esflurbiprofen exerts a fast-onset antidepressant effect by blocking SERT-nNOS interaction. [Abstract]2025 Oct 9. PMID: 41068287 -
Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
Anim Dis
Pasteurella multocida capsular: lipopolysaccharide types D:L6 and A:L3 remain to be the main epidemic genotypes of pigs in China. [Abstract]2021;1(1):26. PMID: 34778886
Pureza y Documentación
Referencias
[1]. Ambekar CS, et al. Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Toxicol In Vitro. 2004;18(4):441-447. [Content Brief]
[2]. Ambrose PJ, et al. Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984;9(3):222-238. [Content Brief]
[3]. Tian S, et al. Computational discovery and repurposing of chloramphenicol succinate as a potent P2Y14 receptor antagonist for inflammatory bowel disease therapy. J Adv Res. Published online August 22, 2025. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chloramphenicol succinate Related Classifications
HY-N7114 Related Classifications
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