DHODH-IN-13
DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis.
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- No. CAS: 1364791-86-5
- Fòrmula: C10H6F3N3O3
- Peso molecular:273.17
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
IC50: 4.3 μM for (Rat liver DHODH)[1]
DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1364791-86-5
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Peso molecular 273.17
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Fòrmula C10H6F3N3O3
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SMILES
O=C(C1=NONC1=O)NC2=CC=C(C(F)(F)F)C=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DHODH-IN-13 Related Classifications
HY-135677 Related Classifications
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