ANXA1 - annexin A1 Gene

Also Known as ANX1; LPC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 301

About ANXA1

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:73,151,865-73,170,393 (from NCBI)

This gene has 8 transcripts (splice variants), 306 orthologues and 12 paralogues. Biased expression in esophagus (RPKM 2850.3), bone marrow (RPKM 574.5) and 4 other tissues.

Summary

This gene encodes a membrane-localized protein that binds Phospholipids. This protein inhibits Phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]

ANXA1 Products (1)

mRNA	Protein	Name
NM_000700.3	NP_000691.1	annexin A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables calcium ion binding	EXP EXP: Inferred from Experiment	11078886	GOA
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	2138016	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	15226301	GOA
enables lipid binding	EXP EXP: Inferred from Experiment	8756690	GOA
enables phospholipase A2 inhibitor activity	IDA IDA: Inferred from direct assay	2936963	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20029029	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA IDA: Inferred from direct assay	25664854	GOA
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP IMP: Inferred from mutant phenotype	15187149	GOA
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15187149	GOA
involved in cellular response to glucocorticoid stimulus	IDA IDA: Inferred from direct assay	2936963	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	22773844	GOA
involved in granulocyte chemotaxis	IDA IDA: Inferred from direct assay	15187149	GOA
involved in keratinocyte differentiation	IDA IDA: Inferred from direct assay	10908733	GOA
involved in monocyte chemotaxis	IDA IDA: Inferred from direct assay	15187149	GOA
involved in negative regulation of T-helper 2 cell differentiation	IDA IDA: Inferred from direct assay	17008549	GOA
involved in negative regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	19625660	GOA
involved in negative regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	22056994	GOA
involved in neutrophil activation	IDA IDA: Inferred from direct assay	22879591	GOA
involved in neutrophil clearance	IMP IMP: Inferred from mutant phenotype	21957127	GOA
involved in neutrophil homeostasis	IMP IMP: Inferred from mutant phenotype	21957127	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	10908733	GOA
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	17008549	GOA
involved in positive regulation of T-helper 1 cell differentiation	IDA IDA: Inferred from direct assay	17008549	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	22773844	GOA
involved in positive regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	17008549	GOA
involved in positive regulation of vesicle fusion	IDA IDA: Inferred from direct assay	2138016	GOA
involved in positive regulation of wound healing	IDA IDA: Inferred from direct assay	25664854	GOA
involved in regulation of cell shape	IDA IDA: Inferred from direct assay	15187149	GOA
involved in regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	19625660	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
colocalizes with actin filament	IDA IDA: Inferred from direct assay	22773844	GOA
located in cell surface	IDA IDA: Inferred from direct assay	22056994	GOA
located in cornified envelope	IDA IDA: Inferred from direct assay	10908733	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10772777	GOA
located in endosome	IDA IDA: Inferred from direct assay	18767904	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	25664854	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	17008549	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10772777	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10772777	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANXA1 Protein Structure

Annexin

0
100
200
300
346 a.a.

Protein Preferred Names	Protein Names
annexin A1	annexin I (lipocortin I)

ANXA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	ANXA1	P04083	EVA1B	Homo sapiens	Q9NVM1	Y2H Pooling	32814053
Intra	ANXA1	P04083	EVA1B	Homo sapiens	Q9NVM1	Validated Y2H	32814053
Intra	ANXA1	P04083	EVA1B	Homo sapiens	Q9NVM1	Y2H Array	32814053
Intra	ANXA1	P04083	LNPK	Homo sapiens	Q9C0E8-2	Validated Y2H	32296183
Intra	ANXA1	P04083	LNPK	Homo sapiens	Q9C0E8-2	Y2H Array	32296183
Intra	ANXA1	P04083	LNPK	Homo sapiens	Q9C0E8-2	Y2H Prey Pooling	32296183
Intra	ANXA1	P04083	LEG1	Homo sapiens	Q6P5S2	Validated Y2H	32814053
Intra	ANXA1	P04083	LEG1	Homo sapiens	Q6P5S2	Y2H Pooling	32814053
Intra	ANXA1	P04083	LEG1	Homo sapiens	Q6P5S2	Y2H Array	32814053
Intra	ANXA1	P04083	ZHX1-C8orf76	Homo sapiens	Q96EF9	Y2H Array	32814053
Intra	ANXA1	P04083	ZHX1-C8orf76	Homo sapiens	Q96EF9	Validated Y2H	32814053
Intra	ANXA1	P04083	ZHX1-C8orf76	Homo sapiens	Q96EF9	Y2H Pooling	32814053
Intra	ANXA1	P04083	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029
Intra	ANXA1	P04083	RIPK1	Homo sapiens	Q13546	Confocal	21383699
Intra	ANXA1	P04083	RIPK1	Homo sapiens	Q13546	GMS	21383699
Intra	ANXA1	P04083	IKBKG	Homo sapiens	Q9Y6K9	Anti Bait CoIP	21383699
Intra	ANXA1	P04083	IKBKG	Homo sapiens	Q9Y6K9	GMS	21383699
Intra	ANXA1	P04083	IKBKG	Homo sapiens	Q9Y6K9	Confocal	21383699

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANXA1 Proteins

Referencia número	Nombre del producto	Accession	Pureza
HY-P7512	Annexin A1/ANXA1 Protein, Human	P04083 (A2-N346)	≥ 95%, as determined by reducing SDS-PAGE.

ANXA1 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P80544	Annexin A1/ANXA1 Antibody (YA832)	WB	Human, Mouse, Rat, Monkey
HY-P80544A	Annexin A1/ANXA1 Antibody (YA832)(PBS only)	WB	Human, Mouse, Rat, Monkey
HY-P85949	Annexin A1/ANXA1 Antibody (YA5641)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Shoulder Impingement Syndrome	Impingement Syndrome Of Shoulder Region Subacromial Impingement
Brain Edema	Cerebral Edema Intracranial Swelling Wet Brain
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Hairy Cell Leukemia	Hcl-V Hairy Cell Leukemia Variant Hairy Cell Leukaemia Variant Hcl Leukemic Reticuloendotheliosis Leukemic Reticuloendotheliosis Variant Prolymphocytic Variant Of Hcl Prolymphocytic Variant Of Hairy Cell Leukemia Leukemia Hairy Cell Leukemia, Hairy Cell Leukaemic Reticuloendotheliosis Lre - [Leukemic Reticuloendotheliosis] Hairy-Cell Leukaemia, Nos Hcl - [Hairy Cell Leukaemia] Hairy-Cell Leukaemia Without Mention Of Remission
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Spleen Cancer	Spleen Neoplasm Splenic Neoplasm Splenic Neoplasms Malignant Splenic Tumor Malignant Tumour Of Spleen Tumor Of Spleen Malignant Neoplasm Of Spleen
Splenic Marginal Zone Lymphoma	Smzl Splenic Marginal Zone B-Cell Lymphoma
Fallopian Tube Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of The Fallopian Tube
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Mucocele Of Appendix	Appendicele Mucocele Appendicular Mucocele Appendiceal Mucocele
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-P10412	A11		98.49%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ANXA1	VGNC	VGNC:69944
Bos taurus	ANXA1	VGNC	VGNC:50196
Mus musculus	ANXA1	MGD	MGI:96819
Rattus norvegicus	ANXA1	RGD	RGD:2118
Felis catus	ANXA1	VGNC	VGNC:67681
Canis familiaris	ANXA1	VGNC	VGNC:37937
Others	ANXA1	NCBI