Annexin A1/ANXA1 Antibody (YA5641)

製品番号: HY-P85949: データシート User Guide for Antibodies
FAQs
Technical Support

Annexin A1/ANXA1 Antibody (YA5641) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Annexin A1/ANXA1.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量	価格（税別）	在庫状況	数量
20 μL	$136	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	$200	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	$320	Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

Annexin A1/ANXA1 Antibody (YA5641) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Annexin A1/ANXA1.

Host

Mouse

Clonality

Monoclonal

分子量

Predicted band size: 38 kDa;

Observed band size: 37 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P04083

Gene ID

301 [NCBI]

Immunogen

Synthesized peptide derived from human Annexin A1 AA range: 250-346

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1000
WB WB: Western Blot	1:500-2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-500
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:1000-5000

純度	Protein G	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (By similarity). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions (By similarity). Displays Ca(2+)-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton (By similarity); Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:22879591, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Promotes resolution of inflammation and wound healing (PubMed:25664854). Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2 (PubMed:22879591)

Subcellular Localization：Nucleus; Cytoplasm; Cell projection, cilium; Cell membrane; Membrane; Peripheral membrane protein; Endosome membrane; Peripheral membrane protein; Basolateral cell membrane; Apical cell membrane; Lateral cell membrane; Secreted; Secreted, extracellular space; Cell membrane; Peripheral membrane protein; Extracellular side; Secreted, extracellular exosome; Cytoplasmic vesicle, secretory vesicle lumen; Cell projection, phagocytic cup; Early endosome; Cytoplasmic vesicle membrane; Peripheral membrane protein

Expression：
Tissue_specificity:Detected in resting neutrophils (PubMed: 10772777) . Detected in peripheral blood T cells (PubMed: 17008549) . Detected in extracellular vesicles of inflammatory bowel disease serum, but not detected in serum of healthy donors (PubMed: 25664854) . Detected in placenta (protein level) (PubMed: 2532504) . Detected in liver.

Subunit：Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation (PubMed:2532504).

ドキュメンテーション

User Guide for Antibodies (1077 KB)

Annexin A1/ANXA1 Antibody (YA5641) 関連分類

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Annexin A1/ANXA1 Antibody (YA5641)

Product Detail

Background

説明

Annexin A1/ANXA1 Antibody (YA5641) 関連分類

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