PKD1 - polycystin 1, transient receptor potential channel interacting Gene

Also Known as PBP; PC1; Pc-1; TRPP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5310

About PKD1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,088,708-2,135,898 (from NCBI)

This gene has 40 transcripts (splice variants), 194 orthologues, 10 paralogues and is associated with 3 phenotypes. Ubiquitous expression in endometrium (RPKM 11.1), fat (RPKM 9.6) and 25 other tissues.

Summary

This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008]

PKD1 Products (12)

mRNA	Protein	Name
XM_047434211.1	XP_047290167.1	polycystin-1 isoform X6
XM_047434212.1	XP_047290168.1	polycystin-1 isoform X7
XM_047434210.1	XP_047290166.1	polycystin-1 isoform X5
XM_047434213.1	XP_047290169.1	polycystin-1 isoform X9
XM_005255370.4	XP_005255427.1	polycystin-1 isoform X10
XM_011522529.3	XP_011520831.1	polycystin-1 isoform X4
NM_000296.4	NP_000287.4	polycystin-1 isoform 2 precursor
XM_047434209.1	XP_047290165.1	polycystin-1 isoform X2
XM_011522537.2	XP_011520839.1	polycystin-1 isoform X8
XM_011522528.4	XP_011520830.1	polycystin-1 isoform X3
NM_001009944.3	NP_001009944.3	polycystin-1 isoform 1 precursor
XM_047434208.1	XP_047290164.1	polycystin-1 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	27214281	GOA
contributes to calcium channel activity	IDA IDA: Inferred from direct assay	27214281	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10097141	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	9171830	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17980165	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	9192675	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in Wnt signaling pathway	IDA IDA: Inferred from direct assay	27214281	GOA
involved in branching morphogenesis of an epithelial tube	IDA IDA: Inferred from direct assay	12482949	GOA
involved in calcium ion transport	IDA IDA: Inferred from direct assay	27214281	GOA
involved in cartilage development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	27214281	GOA
involved in digestive tract development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in genitalia development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in heart development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in lung epithelium development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in mesonephric duct development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in mesonephric tubule development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric ascending thin limb development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric collecting duct development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric distal tubule morphogenesis	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric proximal tubule development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in mitocytosis	IDA IDA: Inferred from direct assay	37681898	GOA
involved in neural tube development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16311606	GOA
involved in protein heterotetramerization	IDA IDA: Inferred from direct assay	30093605	GOA
acts upstream of regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	16311606	GOA
acts upstream of or within regulation of proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	23001567	GOA
involved in skin development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in spinal cord development	IEP IEP: Inferred from expression pattern	11891195	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	10770959	GOA
part of calcium channel complex	IDA IDA: Inferred from direct assay	27214281	GOA
part of cation channel complex	IDA IDA: Inferred from direct assay	30093605	GOA
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15326289	GOA
located in membrane	IDA IDA: Inferred from direct assay	30093605	GOA
located in migrasome	IDA IDA: Inferred from direct assay	37681898	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23001567	GOA
part of polycystin complex	IPI IPI: Inferred from physical interaction	11901144	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKD1 Protein Structure

LRRNT

LRR_8

WSC

PKD

Lectin_C

PKD

REJ

GPS

PLAT

PKD_channel

0
700
1400
2100
2800
3500
4303 a.a.

Protein Preferred Names	Protein Names
polycystin-1	autosomal dominant polycystic kidney disease 1 protein polycystic kidney disease 1 (autosomal dominant) polycystic kidney disease-associated protein transient receptor potential cation channel, subfamily P, member 1

PKD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	PKD1	P98161	PKD2	Homo sapiens	Q13563	Anti Tag CoIP	20168298
Intra	PKD1	P98161	PKD2	Homo sapiens	Q13563	Y2H	10097141
Intra	PKD1	P98161	PKD2	Homo sapiens	Q13563-1	Anti Tag CoIP	19556541
Intra	PKD1	P98161	PKD2	Homo sapiens	Q13563-1	Pull Down	19556541

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Isolated Elevated Serum Creatine Phosphokinase Levels	Elevated Serum Cpk Idiopathic Hyperckemia Isolated Hyperckemia Elevated Serum Creatine Phosphokinase H-Ck Idiopathic Persistent Elevation Of Serum Creatine Kinase
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Steatocystoma Multiplex	Sebocystomatosis Multiple Sebaceous Cysts Multiplex Steatocystoma Sebaceous Cysts, Multiple SM
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Multicystic Dysplastic Kidney	Multicystic Renal Dysplasia Multicystic Kidney Dysplasia Mcdk Multiple Congenital Cysts Of Kidney Developmental Multicystic Kidney
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Meckel Syndrome, Type 1	Meckel Syndrome Meckel-Gruber Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Deafness, Autosomal Recessive 77	DFNB77 Autosomal Recessive Nonsyndromic Deafness 77 Autosomal Recessive Deafness 77 Deafness, Autosomal Recessive, 77 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 77 Deafness, Autosomal Recessive, Type 77
Asphyxiating Thoracic Dystrophy	Jeune Thoracic Dystrophy Jeune Syndrome Asphyxiating Thoracic Dysplasia Short-Rib Thoracic Dysplasia With Or Without Polydactyly Thoracic Pelvic Phalangeal Dystrophy Asphyxiating Thoracic Chondrodystrophy Atd Chondroectodermal Dysplasia-Like Syndrome Infantile Thoracic Dystrophy Jeune Thoracic Dysplasia Thoracic Asphyxiant Dystrophy Thoracic-Pelvic-Phalangeal Dystrophy Short-Rib Thoracic Dysplasia Without Polydactyly Asphyxiating Thoracic Dystrophy Of The Newborn Asphyxiating Thorax Dystrophy
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Cerebral Aneurysms	Cerebral Aneurysm Cerebral Arterial Aneurysm
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 2 PKD2 Polycystic Kidney Disease, Adult, Type Ii Apkd2 Polycystic Kidney Disease, Type 2 Adpkd2 Adult Polycystic Kidney Disease Type 2 Autosomal Dominant Polycystic Kidney Disease 2 Pkd-2 Polycystic Kidney Disease Adult Type Ii Polycystic Kidney Type 2 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 2
Kartagener Syndrome	Kartagener'S Syndrome
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Hemangioma	Hemangiomas
Cerebral Arterial Disease	Cerebral Arterial Diseases
Deafness, Autosomal Recessive 66	DFNB66 Autosomal Recessive Nonsyndromic Deafness 66 Autosomal Recessive Deafness 66 Deafness, Autosomal Recessive, 66 Deafness, Autosomal Recessive, Type 66
Nephronophthisis 1	NPHP1 Nephronophthisis, Familial Juvenile Nph1 Nephronophthisis 1, Juvenile Juvenile Nephronophthisis 1 Familial Juvenile Nephronophthisis 1 Nephronophthisis, Type 1
End Stage Renal Disease	End Stage Renal Failure End-Stage Kidney Disease Kidney Failure, Chronic Chronic Kidney Disease Stage 5
Oligohydramnios	Oligohydramnios - Delivered Antepartum Oligohydramnios Delivered Oligohydramnios Oligohydramnios, Antepartum Condition Or Complication Deficient Liquor Oligohydramnios, Unspecified Trimester Reduced Liquor Volume
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Polycystic Kidney Disease, Infantile Severe, With Tuberous Sclerosis	PKDTS Tuberous Sclerosis/Polycystic Kidney Disease Contiguous Gene Syndrome Polycystic Kidneys, Severe Infantile With Tuberous Sclerosis Chromosome 16p13.3 Deletion Syndrome, Distal Tuberous Sclerosis Polycystic Kidney Disease Contiguous Gene Syndrome Autosomal Dominant Polycystic Kidney Disease Type 1 With Tuberous Sclerosis Tsc2/Pkd1 Contiguous Gene Syndrome
Renal Dysplasia, Cystic	CYSRD Renal Dysplasia, Cystic, Susceptibility To Diffuse Cystic Renal Dysplasia Renal Dysplasia Diffuse Cystic Cystic Renal Dysplasia Susceptibility To Cystic Renal Dysplasia Dysplasia, Renal, Cystic, Susceptibility To Multicystic Dysplastic Kidney
Intracranial Berry Aneurysm	Familial Aneurysmal Subarachnoid Hemorrhage Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm Saccular Cerebral Aneurysm Aneurysm, Intracranial Berry Aneurysmal Subarachnoid Hemorrhage Aneurysm, Intracranial Berry, 1
Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a	Multiple Pterygium Syndrome, Autosomal Dominant CPSFS1A Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a Autosomal Dominant Disease Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a Cpskf1a Pterygium Syndrome, Multiple Autosomal Dominant Arthrogryposis, Distal, Type 8, Formerly Da8, Formerly Autosomal Dominant Multiple Pterygium Syndrome Distal Arthrogryposis Type 8 Arthrogryposis, Distal, Type 8 Da8 Pterygium Syndrome, Multiple, Autosomal Dominant Autosomal Dominant Disorder
Autosomal Genetic Disease	Autosomal Hereditary Disorder
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 1 PKD1 Adpkd Polycystic Kidney Disease, Adult, Type I Apkd1 Potter Type Iii Polycystic Kidney Disease Polycystic Kidney Disease, Adult Potter Type Iii Polycystic Kidney Disease, Formerly Polycystic Kidney Disease, Type 1 Adpkd1 Adult Polycystic Kidney Disease Type 1 Autosomal Dominant Polycystic Kidney Disease 1 Pkd-1 Polycystic Kidney Disease Adult Polycystic Kidney Disease Type I Polycystic Kidneys Polycystic Kidney Disease, Adult Type I Polycystic Kidney Type 1 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 1 Polycystic Kidney, Autosomal Dominant Polycystic Kidney, Type 1 Autosomal Dominant Disease Polycystic Kidney Diseases
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Disease Vhl Vhl Syndrome VHLS Von Hippel-Lindau Syndrome, Modifier Of Hippel Lindau Syndrome Angiomatosis Retinae Cerebelloretinal Angiomatosis, Familial Hippel-Lindau Disease Familial Cerebelloretinal Angiomatosis Lindau Disease VHLD
Creatine Phosphokinase, Elevated Serum	Hyperckemia, Idiopathic Cpk, Elevated Serum Hyperckmia HYPCK
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Renovascular Hypertension	Hypertension, Renovascular Hypertension Renovascular
Marfan Syndrome	MFS Mfs1 Marfan'S Syndrome Marfan Syndrome Type 1 Marfan Syndrome, Type I Mass Phenotype Contractural Arachnodactyly Mass Syndrome Octd Overlap Connective Tissue Disease Marfanoid Hypermobility Syndrome Marfan Disease
Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease	PKD3 Polycystic Kidney Disease, Adult, Type Iii Apkd3 Polycystic Kidney Disease 3 Polycystic Kidney Disease, Type 3 Polycystic Kidney Disease 3 Without Polycystic Liver Disease Polycystic Kidney Disease 3, Autosomal Dominant
Nephronophthisis 2	NPHP2 Nph2 Nephronophthisis 2, Infantile Infantile Nephronophthisis 2 Infantile Nephronophthisis Nephronophthisis, Type 2
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Syndactyly, Type I Sd1 Zygodactyly Syndactyly, Type 1, With Or Without Craniosynostosis Non-Syndromic Syndactyly Symphalangism Symphalangy Webbing Of Digits Syndactyly, Type 1
Caroli Disease	Caroli Disease Isolated Congenital Polycystic Dilatation Of Intrahepatic Bile Ducts Cystic Dilatation Of The Intrahepatic Biliary Tree Caroli Syndrome Carolis Disease
Polycystic Liver Disease 1 With Or Without Kidney Cysts	Polycystic Liver Disease 1 PCLD1 Liver Disease, Polycystic, Type 1 Polycystic Liver Disease Cyst

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Phase
HY-15698	CRT0066101	Inhibitor	99.88%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-13687	IKK 16	Inhibitor	99.88%	Unkown
HY-15698A	CRT0066101 dihydrochloride	Inhibitor	99.97%	Unkown
HY-13941	1-Naphthyl PP1	Inhibitor	99.36%	Unkown
HY-13687A	IKK 16 hydrochloride	Inhibitor	99.95%	Unkown
HY-12239	CID755673	Inhibitor	99.13%	Unkown
HY-118052	BPKDi	Inhibitor	99.74%	Unkown
HY-13454	CID 2011756	Inhibitor	96.98%	Unkown
HY-15528	kb NB 142-70	Inhibitor	98.02%	Unkown
HY-128142	PKC/PKD-IN-1	Inhibitor	98.35%	Unkown
HY-151374	3-IN-PP1	Inhibitor	99.37%	Unkown
HY-15698B	CRT0066101 trihydrochloride	Inhibitor	99.23%	Unkown
HY-151372	Protein kinase D inhibitor 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PKD1	RGD	RGD:3333
Bos taurus	PKD1	VGNC	VGNC:32933
Felis catus	PKD1	VGNC	VGNC:82450
Mus musculus	PKD1	MGD	MGI:97603
Canis familiaris	PKD1	VGNC	VGNC:44597
Others	PKD1	NCBI