Hydrocinchonine
Based on 1 Customer Validation
Hydrocinchonine (Dihydrocinchonine) is a multidrug resistance (MDR)-reversal agent. Hydrocinchonine directly inhibits the function and expression of P-gp, which is the mechanism by which it reverses MDR. Hydrocinchonine exerts synergistic apoptotic effect with Paclitaxel (HY-B0015) in MES-SA/DX5 cells. Hydrocinchonine can be used for the study of gynecological malignant tumors (such as uterine sarcoma) with drug resistance caused by excessive expression of P-gp.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.33%
- No. CAS: 485-65-4
- Fòrmula: C19H24N2O
- Peso molecular:296.41
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Natural Product Library
HY-L021
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Anti-Cancer Compound Library
HY-L025
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Alkaloids Library
HY-L071
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HY-L107
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HY-L115
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Cancer Stem Cells Compound Library
HY-L135
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Cell Death Library
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HY-L021P
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Natural Product and Natural Product-Like Compound Library
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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HY-L200
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High-Throughput Bioactive Compound Library
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High-Throughput Natural Product Library
HY-L206
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Mass Spectrometry Human Metabolite Library
HY-L215
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Mass Spectrometry Natural Product Library
HY-L262
Actividad biológica
Hydrocinchonine (10 μM, 24 h) potentiates Paclitaxel (TAX)-induced cytotoxicity in P-gp expressing MES-SA (IC50 = 18.59 nM)/DX5 (IC50 = 632.64 nM) cells and shows no significant toxicity to either of the two cell lines at 100 μM[1].
Hydrocinchonine (10 μM, 24 h) effectively makes drug-resistant cancer cells regain sensitivity to apoptosis induced by TAX, leading to a large number of cell deaths in MES-SA/DX5 cells[1].
Hydrocinchonine (10 μM, 1 h) effectively inhibits the function of P-gp, preventing it from pumping the substrate out of the cell, thereby allowing the drugs to accumulate within the MES-SA/DX5 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MES-SA and MES-DX5 cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Significantly increased the proportion of Sub-G1 cells with TAX.
Activated Caspase-3 and induced PARP cleavage with combined treatment.
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Cell Line:MES-SA and MES-DX5 cells
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Concentration:10 μM
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Incubation Time:1 h
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Result:Treated cells exhibited intense green fluorescence, indicating a potent inhibition of P-gp function.
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Cell Line:MES-SA and MES-DX5 cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Downregulated the protein expression level of P-gp.
Chemical Information
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No. CAS 485-65-4
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Appearance Solid
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Peso molecular 296.41
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Fòrmula C19H24N2O
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Color White to off-white
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SMILES
O[C@@H](C1=CC=NC2=C1C=CC=C2)[C@]3([H])[N@@](CC4)C[C@H](CC)[C@]4([H])C3
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Synonyms
Dihydrocinchonine
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
Ethanol : 4 mg/mL (13.49 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (282 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 3.3737 mL | 16.8685 mL | 33.7371 mL | 84.3426 mL |
| 5 mM | 0.6747 mL | 3.3737 mL | 6.7474 mL | 16.8685 mL | |
| 10 mM | 0.3374 mL | 1.6869 mL | 3.3737 mL | 8.4343 mL |
Hydrocinchonine Related Classifications
HY-W035709 Related Classifications
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