(R)-D2PM
Based on 1 Customer Validation
(R)-D2PM is a dopamine transporter inhibitor. (R)-D2PM is an isomer of D2PM. (R)-D2PM increases dopamine concentration in the synaptic cleft by inhibiting dopamine reuptake, producing central sympathomimetic effects. (R)-D2PM can be used in studies of acute D2PM toxicity and cardiovascular toxicity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.93%
- No. CAS: 22348-32-9
- Fòrmula: C17H19NO
- Peso molecular:253.34
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Almacenamiento:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
In Vitro
(R)-D2PM binds the dopamine re-uptake transporter with Kibinding 0.04 μM and inhibits dopamine re-uptake with Kiuptake 0.17 μM, yielding a Kibinding:Kiuptake ratio of 4.25[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 22348-32-9
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Appearance Solid
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Peso molecular 253.34
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Fòrmula C17H19NO
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Color White to off-white
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SMILES
OC(C1=CC=CC=C1)(C2=CC=CC=C2)[C@@H]3NCCC3
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Synonyms
(R)-Diphenylprolinol
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvente y solubilidad
In Vitro:
DMSO : 10 mg/mL (39.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (280 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Inagaki S, et al. Rapid enantiomeric separation and simultaneous determination of phenethylamines by ultra high performance liquid chromatography with fluorescence and mass spectrometric detection: application to the analysis of illicit drugs distributed in the Japanese market and biological samples. Drug testing and analysis. 2012 Dec;4(12):1001-8. [Content Brief]
[2]. Wood DM, et al. Use and acute toxicity associated with the novel psychoactive substances diphenylprolinol (D2PM) and desoxypipradrol (2-DPMP). Clinical toxicology (Philadelphia, Pa.). 2012 Sep;50(8):727-32. [Content Brief]
[3]. Lidder S, et al. Cardiovascular toxicity associated with recreational use of diphenylprolinol (diphenyl-2-pyrrolidinemethanol [D2PM]). Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2008 Sep;4(3):167-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9473 mL | 19.7363 mL | 39.4726 mL | 98.6816 mL |
| 5 mM | 0.7895 mL | 3.9473 mL | 7.8945 mL | 19.7363 mL | |
| 10 mM | 0.3947 mL | 1.9736 mL | 3.9473 mL | 9.8682 mL | |
| 15 mM | 0.2632 mL | 1.3158 mL | 2.6315 mL | 6.5788 mL | |
| 20 mM | 0.1974 mL | 0.9868 mL | 1.9736 mL | 4.9341 mL | |
| 25 mM | 0.1579 mL | 0.7895 mL | 1.5789 mL | 3.9473 mL | |
| 30 mM | 0.1316 mL | 0.6579 mL | 1.3158 mL | 3.2894 mL |
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