22348-32-9
22348-32-9
Chemical Structure
(R)-D2PM
Synonym(s): (R)-Diphenylprolinol
- CAS No.: 22348-32-9
- Formula:C17H19NO
- Molecular Weight:253.34
IUPAC Name: (R)-diphenyl(pyrrolidin-2-yl)methanol
InChIKey: OGCGXUGBDJGFFY-MRXNPFEDSA-N
SMILES: OC(C1=CC=CC=C1)(C2=CC=CC=C2)[C@@H]3NCCC3
Biological Activity: (R)-D2PM is a dopamine transporter inhibitor. (R)-D2PM is an isomer of D2PM. (R)-D2PM increases dopamine concentration in the synaptic cleft by inhibiting dopamine reuptake, producing central sympathomimetic effects. (R)-D2PM can be used in studies of acute D2PM toxicity and cardiovascular toxicity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(R)-D2PM | 99.93% | (R)-D2PM is a dopamine transporter inhibitor. (R)-D2PM is an isomer of D2PM. (R)-D2PM increases dopamine concentration in the synaptic cleft by inhibiting dopamine reuptake, producing central sympathomimetic effects. (R)-D2PM can be used in studies of acute D2PM toxicity and cardiovascular toxicity. | ||||||||||||||||||||
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BFC220 | BFC220 is a covalent SARS-CoV-2 Mpro inhibitor with an IC50 of 2.77 μM. BFC220 can be used for antiviral research. | |||||||||||||||||||||
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α-Cyclohexyl-α-phenylbenzenemethanol | α-Cyclohexyl-α-phenylbenzenemethanol (88) is a triarylmethane compound. α-Cyclohexyl-α-phenylbenzenemethanol reduces chloride secretion in intestinal epithelial cells by inhibiting basolateral K+ channels (Potassium Channel). α-Cyclohexyl-α-phenylbenzenemethanol is applicable to research related to secretory diarrhea and dysentery. | |||||||||||||||||||||
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Diphenidol hydrochloride (Standard) | ≥98% | Diphenidol (hydrochloride) (Standard) is the analytical standard of Diphenidol (hydrochloride). This product is intended for research and analytical applications. Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea. | ||||||||||||||||||||
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Diphenidol | Diphenidol is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea. | |||||||||||||||||||||
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Azacyclonol hydrochloride | Azacyclonol (γ-pipradol) hydrochloride is a compound with promising anticancer activity, showing effectiveness in inhibiting NOX-derived ROS in A549 human lung cancer cells. Azacyclonol hydrochloride exhibits enhanced proliferation inhibition against androgen-refractory cancer cell lines, specifically DU145 and PC-3. Azacyclonol hydrochloride demonstrates antitumor activity in DU145-xenografted chorioallantoic membrane tumor models. Azacyclonol hydrochloride also acts as a ligand for the M3 muscarinic acetylcholine receptor, which is overexpressed in ARPC. Azacyclonol hydrochloride effectively blocks carbachol-induced proliferation and NOX activity in DU145 cells. Azacyclonol hydrochloride can also be utilized for the treatment of chronic schizophrenia. | |||||||||||||||||||||
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Azacyclonol (Standard) | ≥98% | Azacyclonol (Standard) is the analytical standard of Azacyclonol. This product is intended for research and analytical applications. Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations. | ||||||||||||||||||||
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Pridinol | Pridinol is an orally active, blood-brain permeable, muscarinic acetylcholine receptor (mAChR)-directed muscle relaxant. Pridinol reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases. | |||||||||||||||||||||
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(R)-D2PM hydrochloride | (R)-D2PM hydrochloride is a dopamine transporter inhibitor. (R)-D2PM hydrochloride is an isomer of D2PM. (R)-D2PM hydrochloride increases dopamine concentration in the synaptic cleft by inhibiting dopamine reuptake, producing central sympathomimetic effects. (R)-D2PM hydrochloride can be used in studies of acute D2PM toxicity and cardiovascular toxicity. | |||||||||||||||||||||
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(S)-Desoxy-D2PM hydrochloride | (S)-Desoxy-D2PM ((S)-2-Diphenylmethylpyrrolidine) hydrochloride is a neuroactive compound. | |||||||||||||||||||||
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1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol | 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is an anticholinergic agent. 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol has the potential for the research of bronchial asthma. 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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References
- [1]. Inagaki S, et al. Rapid enantiomeric separation and simultaneous determination of phenethylamines by ultra high performance liquid chromatography with fluorescence and mass spectrometric detection: application to the analysis of illicit drugs distributed in the Japanese market and biological samples. Drug testing and analysis. 2012 Dec;4(12):1001-8. [Content Brief]
- [2]. Wood DM, et al. Use and acute toxicity associated with the novel psychoactive substances diphenylprolinol (D2PM) and desoxypipradrol (2-DPMP). Clinical toxicology (Philadelphia, Pa.). 2012 Sep;50(8):727-32. [Content Brief]
- [3]. Lidder S, et al. Cardiovascular toxicity associated with recreational use of diphenylprolinol (diphenyl-2-pyrrolidinemethanol [D2PM]). Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2008 Sep;4(3):167-9. [Content Brief]
