LY3509754
Based on 4 publication(s) in Google Scholar
LY3509754 (IL-17A inhibitor 1) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.35%
- No. CAS: 2452464-73-0
- Fòrmula: C24H27F5N8O4
- Peso molecular:586.51
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) LY3509754
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Actividad biológica
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IL-17 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NHDF | IC50 |
0.004 μM
Compound: 5; LY3509754
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Inhibition of IL-6 production in IL-17/TNF-alpha stimulated human NHDF cells incubated for 24 hrs by ELISA
Inhibition of IL-6 production in IL-17/TNF-alpha stimulated human NHDF cells incubated for 24 hrs by ELISA
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[PMID: 39276085] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2452464-73-0
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Appearance Solid
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Peso molecular 586.51
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Fòrmula C24H27F5N8O4
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Color Off-white to yellow
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SMILES
O=C(C1=NON=C1C)N[C@@H](C2CCC(F)(CC2)F)C3=CN(N=CC([C@H](N4C[C@H](NC4=O)C(F)(F)F)COC)=C5)C5=N3
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Synonyms
IL-17A inhibitor 1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Bioact Mater
Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration. [Abstract]2024 Mar 15:37:51-71. PMID: 38515609 -
Phytomedicine
Demethylzeylasteral ameliorates podocyte damage in murine lupus by inhibiting inflammation and enhancing autophagy. [Abstract]2024 Aug 15:134:155966. PMID: 39241387 -
Fish Shellfish Immunol
Genome-wide characterization of the interleukin gene family in Nile tilapia (Oreochromis niloticus) spleen: identification, expression dynamics, and regulatory mechanism during Streptococcus agalactiae infection. [Abstract]2025 Dec 12:169:111072. PMID: 41391594 -
Solvente y solubilidad
DMSO : 250 mg/mL (426.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.55 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.55 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7050 mL | 8.5250 mL | 17.0500 mL | 42.6250 mL |
| 5 mM | 0.3410 mL | 1.7050 mL | 3.4100 mL | 8.5250 mL | |
| 10 mM | 0.1705 mL | 0.8525 mL | 1.7050 mL | 4.2625 mL | |
| 15 mM | 0.1137 mL | 0.5683 mL | 1.1367 mL | 2.8417 mL | |
| 20 mM | 0.0853 mL | 0.4263 mL | 0.8525 mL | 2.1313 mL | |
| 25 mM | 0.0682 mL | 0.3410 mL | 0.6820 mL | 1.7050 mL | |
| 30 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4208 mL | |
| 40 mM | 0.0426 mL | 0.2131 mL | 0.4263 mL | 1.0656 mL | |
| 50 mM | 0.0341 mL | 0.1705 mL | 0.3410 mL | 0.8525 mL | |
| 60 mM | 0.0284 mL | 0.1421 mL | 0.2842 mL | 0.7104 mL | |
| 80 mM | 0.0213 mL | 0.1066 mL | 0.2131 mL | 0.5328 mL | |
| 100 mM | 0.0171 mL | 0.0853 mL | 0.1705 mL | 0.4263 mL |
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