Mahanine
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Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.
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- Pureza: 97.0%
- No. CAS: 28360-49-8
- Fòrmula: C23H25NO2
- Peso molecular:347.45
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Almacenamiento:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Actividad biológica
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Leishmania |
Mahanine (0-50 μM; 24 or 48 hours) induces a dose-dependent decrease in cell viability of AG83 promastigotes after 24 hr and 48 hr; the IC50 values were 16.7±1.7 μM and 11.5±0.8 μM respectively. In a drug resistant GE1 strain, Mahanine treatment exhibits dose-dependent cell death in 24 and 48 hr treatment with IC50 values 40.3±2.2 μM and 29.1±1.3 μM respectively[1].Mahanine (5.0 and 10 μM; 24 hours) exhibits increased accumulation of cells at G2/M phase being 39.0±1.90% and 41.0±2.10% respectively compared to untreated promastigotes (35.3 ± 2.60%) in AG83 promastigote [1].Mahanine (25 μM; 24 hours) exhibitssignificantly increased intracellular ROS level within 20 min (MFI being 889 ± 26) which reached to 1288 ± 56 after one hour compared to the basal level (604 ± 34) in untreated promastigote. H2DCFDA positivity was measured by FACS[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice with virulent AG83 promastigotes[1]
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Dosage:20 mg/kg-40 mg/kg
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Administration:oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days
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Result:Had the potential to clear parasite burden in vivo.Exhibited almost complete reduction of parasite burden, upregulation of NO/iNOS/ROS/IL-12 and T cell proliferation in vivo.
Chemical Information
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No. CAS 28360-49-8
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Appearance Solid
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Peso molecular 347.45
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Fòrmula C23H25NO2
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Color Light yellow to brown
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SMILES
OC1=CC2=C(C3=C(N2)C4=C(C(C)=C3)O[C@@](CC/C=C(C)/C)(C)C=C4)C=C1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Kaushik Bhattacharya, et al. Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem Pharmacol. 2010 Feb 1;79(3):361-72. [Content Brief]
[2]. Saptarshi Roy, et al. Mahanine exerts in vitro and in vivo antileishmanial activity by modulation of redox homeostasis. Sci Rep [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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