MI-1481
MI-1481 is a highly potent inhibitor of the Menin-MLL1 interaction with IC50 of 3.6 nM. MI-1481 markedly reduces cell growth of murine bone marrow cells transformed and inhibits leukemia progression.
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- No. CAS: 1887178-64-4
- Fòrmula: C29H30F3N7O2S
- Peso molecular:597.65
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Bone marrow cell | GI50 |
>6 μM
Compound: (S)-28; MI-1481
|
Cytotoxicity against mouse bone marrow cells transformed with control oncogenes Hoxa9/Meis1 assessed as cell growth inhibition after 7 days by MTT assay
Cytotoxicity against mouse bone marrow cells transformed with control oncogenes Hoxa9/Meis1 assessed as cell growth inhibition after 7 days by MTT assay
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[PMID: 29738674] |
| K562 | GI50 |
>6 μM
Compound: (S)-28; MI-1481
|
Cytotoxicity against human K562 cells assessed as cell growth inhibition after 7 days by MTT assay
Cytotoxicity against human K562 cells assessed as cell growth inhibition after 7 days by MTT assay
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[PMID: 29738674] |
| MOLM-13 | GI50 |
61 nM
Compound: (S)-28; MI-1481
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Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 7 days by MTT assay
Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 7 days by MTT assay
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[PMID: 29738674] |
| MV4-11 | GI50 |
36 nM
Compound: (S)-28; MI-1481
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Cytotoxicity against human MV411 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 7 days by MTT assay
Cytotoxicity against human MV411 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 7 days by MTT assay
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[PMID: 29738674] |
| U-937 | GI50 |
>6 μM
Compound: (S)-28; MI-1481
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Cytotoxicity against human U937 cells assessed as cell growth inhibition after 7 days by MTT assay
Cytotoxicity against human U937 cells assessed as cell growth inhibition after 7 days by MTT assay
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[PMID: 29738674] |
Chemical Information
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No. CAS 1887178-64-4
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Peso molecular 597.65
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Fòrmula C29H30F3N7O2S
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SMILES
N#CC(N1C[C@@H](OC2)CNC2=O)=CC3=C1C=CC(CN4CCC(NC5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)CC4)=C3C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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