Ontazolast
Ontazolast (BIRM 270) is a potent inhibitor of LTB4 biosynthesis. Ontazolast can be used in research on asthma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 147432-77-7
- Fòrmula: C21H25N3O
- Peso molecular:335.44
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Chemical Information
-
No. CAS 147432-77-7
-
Peso molecular 335.44
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Fòrmula C21H25N3O
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SMILES
CC1=CC=C2OC(N[C@H](C3=CC=CC=N3)CC4CCCCC4)=NC2=C1
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Synonyms
BIRM-270
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvente y solubilidad
DMSO : 100 mg/mL (298.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.45 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
Referencias
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9812 mL | 14.9058 mL | 29.8116 mL | 74.5290 mL |
| 5 mM | 0.5962 mL | 2.9812 mL | 5.9623 mL | 14.9058 mL | |
| 10 mM | 0.2981 mL | 1.4906 mL | 2.9812 mL | 7.4529 mL | |
| 15 mM | 0.1987 mL | 0.9937 mL | 1.9874 mL | 4.9686 mL | |
| 20 mM | 0.1491 mL | 0.7453 mL | 1.4906 mL | 3.7264 mL | |
| 25 mM | 0.1192 mL | 0.5962 mL | 1.1925 mL | 2.9812 mL | |
| 30 mM | 0.0994 mL | 0.4969 mL | 0.9937 mL | 2.4843 mL | |
| 40 mM | 0.0745 mL | 0.3726 mL | 0.7453 mL | 1.8632 mL | |
| 50 mM | 0.0596 mL | 0.2981 mL | 0.5962 mL | 1.4906 mL | |
| 60 mM | 0.0497 mL | 0.2484 mL | 0.4969 mL | 1.2421 mL | |
| 80 mM | 0.0373 mL | 0.1863 mL | 0.3726 mL | 0.9316 mL | |
| 100 mM | 0.0298 mL | 0.1491 mL | 0.2981 mL | 0.7453 mL |
Ontazolast Related Classifications
HY-105176 Related Classifications
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