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Referencia número: HY-N20723

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Ovalichromene B

Ovalichromene B is a flavonone and phytochemical with an IC₅₀ of 78.83 ± 1.04 μM, found in the dry stem of Pongamia pinnata (L.) Pierre.Ovalichromene B inhibits lipopolysaccharide-induced nitric oxide production.Ovalichromene B exhibits high intestinal absorption, non-mutagenicity, non-hepatotoxicity, and no predicted hERG I or II channel inhibition.Ovalichromene B can be used for the research of neurodegenerative diseases.Ovalichromene B can be used for the research of carbapenem-resistant enterobacterales infections.

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No. CAS: 62868-06-8
Fòrmula: C₂₁H₁₈O₅
Peso molecular:350.37

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Please store the product under the recommended conditions in the Certificate of Analysis.

Ovalichromene B Chemical Structure

No. CAS: 62868-06-8

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Actividad biológica

Descripciòn

Ovalichromene B is a flavonone and phytochemical with an IC₅₀ of 78.83 ± 1.04 μM, found in the dry stem of Pongamia pinnata (L.) Pierre^[1].Ovalichromene B inhibits lipopolysaccharide-induced nitric oxide production^[1].Ovalichromene B exhibits high intestinal absorption, non-mutagenicity, non-hepatotoxicity, and no predicted hERG I or II channel inhibition^[2].Ovalichromene B can be used for the research of neurodegenerative diseases^[1].Ovalichromene B can be used for the research of carbapenem-resistant enterobacterales infections^[2].

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In Vitro

Ovalichromene B (0.1-100 μM) weakly inhibits LPS-induced nitric oxide production in BV-2 microglial cells with an IC₅₀ of 78.83 μM and shows no cytotoxicity at concentrations up to 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 62868-06-8
Peso molecular 350.37
Fòrmula C₂₁H₁₈O₅
SMILES

O=C1C2=C(C3=C(C=C2)OC(C)(C)C=C3)O[C@@H](C1)C=4C=C5C(=CC4)OCO5
Structure Classification
- Flavonoids
- Other Flavonoids
Initial Source
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Li J, et al. Natural therapeutic agents for neurodegenerative diseases from a traditional herbal medicine Pongamia pinnata (L.) Pierre. Bioorganic & medicinal chemistry letters. 2015 Jan 01;25(1):53-8. [Content Brief]

[2]. Jangid H, et al. Structure-Based Identification of Ponganone V from Pongamia pinnata as a Potential KPC-2 β-Lactamase Inhibitor: Insights from Docking, ADMET, and Molecular Dynamics. Microbiology Research. 2025;16(12):262.

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Ovalichromene B

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