62868-06-8
Chemical Structure
Ovalichromene B
- CAS No.: 62868-06-8
- Formula:C21H18O5
- Molecular Weight:350.37
IUPAC Name: (S)-2-(benzo[d][1,3]dioxol-5-yl)-8,8-dimethyl-2,3-dihydro-4H,8H-pyrano[2,3-f]chromen-4-one
InChIKey: JRTNAZKQGYGUQE-SFHVURJKSA-N
SMILES: O=C1C2=C(C3=C(C=C2)OC(C)(C)C=C3)O[C@@H](C1)C=4C=C5C(=CC4)OCO5
Biological Activity: Ovalichromene B is a flavonone and phytochemical with an IC50 of 78.83 ± 1.04 μM, found in the dry stem of Pongamia pinnata (L.) Pierre[1].Ovalichromene B inhibits lipopolysaccharide-induced nitric oxide production[1].Ovalichromene B exhibits high intestinal absorption, non-mutagenicity, non-hepatotoxicity, and no predicted hERG I or II channel inhibition[2].Ovalichromene B can be used for the research of neurodegenerative diseases[1].Ovalichromene B can be used for the research of carbapenem-resistant enterobacterales infections[2].
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Ovalichromene B | Ovalichromene B is a flavonone and phytochemical with an IC50 of 78.83 ± 1.04 μM, found in the dry stem of Pongamia pinnata (L.) Pierre.Ovalichromene B inhibits lipopolysaccharide-induced nitric oxide production.Ovalichromene B exhibits high intestinal absorption, non-mutagenicity, non-hepatotoxicity, and no predicted hERG I or II channel inhibition.Ovalichromene B can be used for the research of neurodegenerative diseases.Ovalichromene B can be used for the research of carbapenem-resistant enterobacterales infections. | |||||||||||||||||||||
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References
- [1]. Li J, et al. Natural therapeutic agents for neurodegenerative diseases from a traditional herbal medicine Pongamia pinnata (L.) Pierre. Bioorganic & medicinal chemistry letters. 2015 Jan 01;25(1):53-8. [Content Brief]
- [2]. Jangid H, et al. Structure-Based Identification of Ponganone V from Pongamia pinnata as a Potential KPC-2 β-Lactamase Inhibitor: Insights from Docking, ADMET, and Molecular Dynamics. Microbiology Research. 2025;16(12):262.
