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Art. -Nr.: HY-N20723

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Ovalichromene B

Ovalichromene B is a flavonone and phytochemical with an IC₅₀ of 78.83 ± 1.04 μM, found in the dry stem of Pongamia pinnata (L.) Pierre.Ovalichromene B inhibits lipopolysaccharide-induced nitric oxide production.Ovalichromene B exhibits high intestinal absorption, non-mutagenicity, non-hepatotoxicity, and no predicted hERG I or II channel inhibition.Ovalichromene B can be used for the research of neurodegenerative diseases.Ovalichromene B can be used for the research of carbapenem-resistant enterobacterales infections.

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CAS. Nr.: 62868-06-8
Formel: C₂₁H₁₈O₅
Molecular Weight:350.37

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Please store the product under the recommended conditions in the Certificate of Analysis.

Ovalichromene B Chemical Structure

CAS. Nr.: 62868-06-8

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Biologische Aktivität
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Chemical Information
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Biologische Aktivität

Beschreibung

Ovalichromene B is a flavonone and phytochemical with an IC₅₀ of 78.83 ± 1.04 μM, found in the dry stem of Pongamia pinnata (L.) Pierre^[1].Ovalichromene B inhibits lipopolysaccharide-induced nitric oxide production^[1].Ovalichromene B exhibits high intestinal absorption, non-mutagenicity, non-hepatotoxicity, and no predicted hERG I or II channel inhibition^[2].Ovalichromene B can be used for the research of neurodegenerative diseases^[1].Ovalichromene B can be used for the research of carbapenem-resistant enterobacterales infections^[2].

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In Vitro

Ovalichromene B (0.1-100 μM) weakly inhibits LPS-induced nitric oxide production in BV-2 microglial cells with an IC₅₀ of 78.83 μM and shows no cytotoxicity at concentrations up to 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 62868-06-8
Molecular Weight 350.37
Formel C₂₁H₁₈O₅
SMILES

O=C1C2=C(C3=C(C=C2)OC(C)(C)C=C3)O[C@@H](C1)C=4C=C5C(=CC4)OCO5
Structure Classification
- Flavonoids
- Other Flavonoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Li J, et al. Natural therapeutic agents for neurodegenerative diseases from a traditional herbal medicine Pongamia pinnata (L.) Pierre. Bioorganic & medicinal chemistry letters. 2015 Jan 01;25(1):53-8. [Content Brief]

[2]. Jangid H, et al. Structure-Based Identification of Ponganone V from Pongamia pinnata as a Potential KPC-2 β-Lactamase Inhibitor: Insights from Docking, ADMET, and Molecular Dynamics. Microbiology Research. 2025;16(12):262.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ovalichromene B

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