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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
IDE
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "IDE" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: LXS196; IDE196
Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research .
2
2 Cited Publications
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Áreas de investigación:
6bK TFA is a selective insulin-degrading enzyme (IDE) inhibitor with an IC50 of 50 nM. 6bK TFA binds to the distal pocket of IDE, thereby blocking substrate binding, peptide unfolding and cleavage processes, and reducing the degradation of insulin, glucagon and amylin. 6bK TFA improves oral glucose tolerance but impairs intraperitoneal glucose tolerance. 6bK TFA can be used in research related to type 2 diabetes .
1
1 Cited Publications
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Áreas de investigación:
IDE1 is an inducer of definitive endoderm 1.
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1 Cited Publications
Áreas de investigación:
ML345 is a potent and selective inhibitor of insulin-degrading enzyme (IDE) and NLRP3, with an IC50 of 188 nM against IDE. ML345 targets the Cys819 residue of IDE to inhibit IDE. ML345 selectively binds to NLRP3 in a non-covalent manner. ML345 inhibits inflammatory cytokines (IL-1β, IL-6) and exhibits potent anti-inflammatory activity. ML345 exerts a protective effect against miscarriage .
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Category:
Olax imbricata Ketones, Aldehydes, Acids Olacaceae Other Diseases Plants Disease Research Fields
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1
1 Cited Publications
Referencia número: HY-W157689
No. CAS: 49619-58-1
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Áreas de investigación:
IDE-IN-2 (Compound 4) is an inhibitor for insulin-degrading enzyme. IDE-IN-2 is predicted to have CYP3A4, CYP2C19, hERG, NADP+, HIF1α and histidine kinase inhibitory activities, and has potential biological activity in anti-diabetic, anti-tumor, anti-bacterial aspects, according to the in silico prediction .
Referencia número: HY-169422
No. CAS: 3064599-36-3
Synonyms: IDE275
Target:
Áreas de investigación:
GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC) .
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Áreas de investigación:
IDE2 is a small molecule cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) by activating the TGF-βsignaling pathway .
Referencia número: HY-169422A
No. CAS: 3064599-37-4
Synonyms: IDE275 (enantiomer)
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Áreas de investigación:
GSK4418959 enantiomer is an enantiomer of GSK4418959 (HY-169422). GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer .
Referencia número: HY-143401
No. CAS: 2785377-42-4
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Áreas de investigación:
Hit 1 is an activator of ansulin degrading enzyme (IDE), with an EC50 of 5.5 μM. Hit 1 can decrease glucose-stimulating insulin secretion .
Referencia número: HY-12655
No. CAS: 1417537-93-9
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Áreas de investigación:
IDE-IN-1 (compound 6bK) is an insulin-degrading enzyme (IDE) inhibitor with IC50 value of 50 nM. IDE-IN-1 can be used to study type 2 diabetes .
Referencia número: HY-114611
No. CAS: 2011754-00-8
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Áreas de investigación:
BDM44768 is an inhibitior of IDE. BDM44768 exacerbates ER stress-induced IRE1 activation and promotes lipid accumulation in hepatocytes. BDM44768 potentiates activation of the IRE1 pathway in the liver and exacerbates liver lipid accumulation in an acute mice model of ER stress .
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Referencia número: HY-RS06526
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Áreas de investigación:
IDE Human Pre-designed siRNA Set A contains three designed siRNAs for IDE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS16920
Target:
Áreas de investigación:
Ide Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ide gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-W616806
No. CAS: 45738-97-4
Referencia número: HY-W103371R
No. CAS: 6155-57-3
Synonyms: o-SulfobenzimIDE sodium salt dihydrate (Standard)
Target:
Sodium 3-oxo-3H-benzo[d]isothiazol-2-ide 1,1-dioxide dihydrate (Standard) is the analytical standard of Sodium 3-oxo-3H-benzo[d]isothiazol-2-ide 1,1-dioxide dihydrate. This product is intended for research and analytical applications.
Referencia número: HY-100533R
No. CAS: 1160927-48-9
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Áreas de investigación:
IDE1 (Standard) is the analytical standard of IDE1 (HY-100533). This product is intended for research and analytical applications. IDE1 is an inducer of definitive endoderm 1.
Referencia número: HY-RS23363
Target:
Áreas de investigación:
Ide Rat Pre-designed siRNA Set A contains three designed siRNAs for Ide gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
