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Referencia número: HY-150559

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SMS2-IN-3

SMS2-IN-3 is a potent and selective SMS2inhibitor (IC₅₀=2.2 nM), significantly reduces the hepatic SM (22:0) levels.

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No. CAS: 2414240-89-2
Fòrmula: C₃₃H₃₉F₃N₄O₆
Peso molecular:644.68

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

SMS2-IN-3 Chemical Structure

No. CAS: 2414240-89-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

SMS2-IN-3 is a potent and selective SMS2inhibitor (IC₅₀=2.2 nM), significantly reduces the hepatic SM (22:0) levels^[1].

IC₅₀ & Target

IC50: 2.2nM (SMS2)^[1]

Ver todos los productos específicos de isoformas Phospholipase :

In Vitro

SMS2-IN-3 (37) is an excellent sphingomyelin synthase 2 inhibitor (SMS2). SMS2-IN-3 (37) has inhibition (IC₅₀= 2.2 nM) and good selectivity against SMS1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

FreeStyle293 cells
Concentration:

100mg/kg
Incubation Time:

60 min
Result:

Showed excellent SMS2 inhibition and good selectivity against SMS1 in biological evaluation.

In Vivo

SMS2-IN-3 (37) has excellent SMS2 activity and high selectivity against SMS1. SMS2-IN-3 also reduces the level of SM by subcutaneous treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

KK-Ay/Ta mice^[1]
Dosage:

100, 200 mg/kg
Administration:

SMS2-IN-3: s.c. (100, 200 mg/kg); p.o. (100, 200 mg/kg); once or twice per day for 7 days.
Result:

cmpd C_max, (μg/mL) T_max, (h) C_{24 h}, (μg/mL) AUC_0-24(μg•h/mL) MRT(h)

37(p.o.) 6.5 0.83 0.007 18 3.0

37(s.c.) 0.70 8.0 0.23 12 9.4

Chemical Information

No. CAS 2414240-89-2
Peso molecular 644.68
Fòrmula C₃₃H₃₉F₃N₄O₆
SMILES

O=C(N1CCC(CCCOC(C2=C(N3C)N=CC=C2)=C(C(N(CC4=CC(OC)=CC(C(F)(F)F)=C4)C)=O)C3=O)CC1)OC5(CC5)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Takafumi Yukawa, et al. Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor. Bioorg Med Chem. 2020 Apr 1;28(7):115376. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

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cmpd	C_max, (μg/mL)	T_max, (h)	C_{24 h}, (μg/mL)	AUC_0-24(μg•h/mL)	MRT(h)
37(p.o.)	6.5	0.83	0.007	18	3.0
37(s.c.)	0.70	8.0	0.23	12	9.4

SMS2-IN-3

Ver todos los productos específicos de isoformas Phospholipase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

SMS2-IN-3 Related Classifications

HY-150559 Related Classifications