XYDC2050
XYDC2050 (Compound 29) is a selective vasopressin V2 receptor (V2R) antagonist with an IC50 of 27 nM and a Ki of 2.8 nM. XYDC2050 shows a Ki of 420.7 nM (SI = 162 fold) for V1R. XYDC2050 can inhibit Vasopressin (HY-B1811)-induced intracellular cyclic adenosine monophosphate (cAMP) accumulation with an IC50 of 12 nM. XYDC2050 can inhibit the growth of renal cysts, reduce the ratio of kidney weight to body weight and decrease the area of cysts and the cystic index. XYDC2050 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).
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- Fòrmula: C33H25FN2O4
- Peso molecular:532.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Vasopressin Receptor
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Actividad biológica
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V2 Receptor 27 nM (IC50) |
V2 Receptor 2.8 nM (Ki) |
Chemical Information
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Peso molecular 532.56
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Fòrmula C33H25FN2O4
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SMILES
FC1=CC=C(N(CC2=CC=C(O)C=C2)C(C3=CC(O)=C(NC(C4=CC=CC=C4C5=CC=CC=C5)=O)C=C3)=O)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XYDC2050 Related Classifications
HY-180142 Related Classifications
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