PPIF - peptidylprolyl isomerase F Gene

Also Known as CYP3; CypD; CyP-M; Cyp-D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10105

About PPIF

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:79,347,469-79,355,334 (from NCBI)

This gene has 5 transcripts (splice variants), 214 orthologues and 22 paralogues. Ubiquitous expression in adrenal (RPKM 72.6), bone marrow (RPKM 44.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]

PPIF Products (1)

mRNA	Protein	Name
NM_005729.4	NP_005720.1	peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	20676357	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22726440	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	22726440	GOA
involved in mitochondrial outer membrane permeabilization involved in programmed cell death	IMP IMP: Inferred from mutant phenotype	26387735	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19228691	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19228691	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	19228691	GOA
involved in regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	26387735	GOA
involved in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	IMP IMP: Inferred from mutant phenotype	22726440	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of mitochondrial permeability transition pore complex	IDA IDA: Inferred from direct assay	26387735	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPIF Protein Structure

Pro_isomerase

0
100
207 a.a.

Protein Preferred Names	Protein Names
peptidyl-prolyl cis-trans isomerase F, mitochondrial	PPIase F

PPIF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	AGTRAP	Homo sapiens	Q6RW13-2	Validated Y2H	32296183
Intra	PPIF	P30405	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Array	32296183
Intra	PPIF	P30405	AGTRAP	Homo sapiens	Q6RW13-2	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	PRB3	Homo sapiens	Q04118	Y2H Array	32296183
Intra	PPIF	P30405	PRB3	Homo sapiens	Q04118	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	PRB3	Homo sapiens	Q04118	Validated Y2H	32296183
Intra	PPIF	P30405	FAM25C	Homo sapiens	B3EWG5	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	FAM25C	Homo sapiens	B3EWG5	Y2H Array	32296183
Intra	PPIF	P30405	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	PPIF	P30405	CMTM5	Homo sapiens	Q96DZ9	Y2H Prey Pooling	25416956
Intra	PPIF	P30405	CMTM5	Homo sapiens	Q96DZ9	Validated Y2H	25416956
Intra	PPIF	P30405	CMTM5	Homo sapiens	Q96DZ9	Y2H Array	25416956
Intra	PPIF	P30405	YIF1A	Homo sapiens	O95070	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	YIF1A	Homo sapiens	O95070	Y2H Array	32296183
Intra	PPIF	P30405	SYPL1	Homo sapiens	Q16563	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	SYPL1	Homo sapiens	Q16563	Validated Y2H	32296183
Intra	PPIF	P30405	SYPL1	Homo sapiens	Q16563	Y2H Array	32296183
Intra	PPIF	P30405	TP53	Homo sapiens	P04637	Anti Bait CoIP	22726440
Intra	PPIF	P30405	TP53	Homo sapiens	P04637	Pull Down	22726440
Intra	PPIF	P30405	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	PPIF	P30405	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	PPIF	P30405	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	ARFIP2	Homo sapiens	P53365	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	ARFIP2	Homo sapiens	P53365	Validated Y2H	32296183
Intra	PPIF	P30405	ARFIP2	Homo sapiens	P53365	Y2H Array	32296183
Intra	PPIF	P30405	CIDEB	Homo sapiens	Q9UHD4	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	CIDEB	Homo sapiens	Q9UHD4	Y2H Array	32296183
Intra	PPIF	P30405	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	PPIF	P30405	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	PPIF	P30405	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	PPIF	P30405	MAGEA11	Homo sapiens	P43364	Validated Y2H	32296183
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9	Y2H Array	25416956
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9	Validated Y2H	25416956
Intra	PPIF	P30405	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	PPIF	P30405	BANP	Homo sapiens	Q8N9N5	Y2H Prey Pooling	25416956
Intra	PPIF	P30405	BANP	Homo sapiens	Q8N9N5	Validated Y2H	25416956
Intra	PPIF	P30405	BANP	Homo sapiens	Q8N9N5	Y2H Array	25416956
Intra	PPIF	P30405	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	SPR	32825572
Intra	PPIF	P30405	SYP	Homo sapiens	P08247	Y2H Array	32296183
Intra	PPIF	P30405	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPIF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74211	Cyclophilin F/PPIF Protein, Human (HEK293, His, solution)	P30405 (C30-S207)	≥ 90%, as determined by reducing SDS-PAGE.

PPIF Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82857	Cyclophilin F Antibody (YA2602)	WB, IHC-P	Human, Mouse, Rat
HY-P82857A	Cyclophilin F Antibody (YA2602)(PBS only)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ullrich Congenital Muscular Dystrophy 1	Ullrich Congenital Muscular Dystrophy Ullrich Disease Ucmd Ullrich Scleroatonic Muscular Dystrophy Scleroatonic Muscular Dystrophy UCMD1 Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 22 Lgmdr22 Muscular Dystrophy, Scleroatonic Late Onset Scleroatonic Familial Myopathy Congenital Muscular Dystrophy, Ullrich Type
Bethlem Myopathy 1	Bethlem Myopathy Myopathy, Benign Congenital, With Contractures Muscular Dystrophy, Benign Congenital BTHLM1 Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 5 Lgmdd5 Benign Congenital Muscular Dystrophy Benign Autosomal Dominant Myopathy Myopathy, Bethlem Myopathy, Bethlem, Type 1
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10951	PPIF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179416	CypD-IN-6	Inhibitor	/	Unkown
HY-179417	CypD-IN-7	Inhibitor	/	Unkown
HY-RS18784	Ppif Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25273	Ppif Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPIF	VGNC	VGNC:33198
Mus musculus	PPIF	MGD	MGI:2145814
Felis catus	PPIF	VGNC	VGNC:97563
Rattus norvegicus	PPIF	RGD	RGD:628670
Macaca mulatta	PPIF	VGNC	VGNC:81510
Others	PPIF	NCBI