2. Immunology/Inflammation
  3. Cyclophilin
  4. CypD-IN-7

CypD-IN-7 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 2.4 nM) and provides protection against mitochondrial permeability transition pore (MPTP) opening. CypD-IN-7 can be used for pancreatitis research.

For research use only. We do not sell to patients.

CypD-IN-7

CypD-IN-7 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

CypD-IN-7 Related Antibodies

Top Publications Citing Use of Products

View All Cyclophilin Isoform Specific Products:

View All Isoforms
Cyclophilin A Cyclophilin B Cyclophilin C Cyclophilin D Cyclophilin G Cyclophilin E

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CypD-IN-7 is a potent cyclophilin D (CypD/PPIF) inhibitor that inhibits CypD PPIase activity (Ki = 2.4 nM) and provides protection against mitochondrial permeability transition pore (MPTP) opening. CypD-IN-7 can be used for pancreatitis research[1].

IC50 & Target1

Cyclophilin D

2.4 nM (Ki)

In Vitro

CypD-IN-7 (18f) (39 nM-5 μM) increases mitochondrial calcium retention capacity (CRC) in isolated mouse liver mitochondria[1].
CypD-IN-7 (10 μM) markedly increases mitochondrial calcium retention capacity (CRC), and provides significantly superior protection against MPTP opening versus cyclosporin A (CsA) at 300 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CypD-IN-7 Related Antibodies
Parmacokinetics
Species Dose Route Tmax Cmax T1/2 AUClast AUCinf
Mice[1] 20 mg/kg i.p. 2.00 h 1633 ng/mL 3.70 h 8860 ng·h/mL 8940 ng·h/mL
In Vivo

CypD-IN-7 (18f) (50 mg/kg; i.p.; dosed immediately after the 3rd and 6th Caerulein (HY-A0190) injections and 2 h after the 7th injection) significantly reduces serum amylase, pancreatic MPO activity, edema/inflammation scores, and total histology score in a caerulein-induced acute pancreatitis (CER-AP) mouse model, whereas 20 mg/kg shows no significant effect[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type C57BL6/J male and female mice (10-12 weeks old); CER-AP induced by 7 hourly i.p. injections of caerulein (50 μg/kg)1
Dosage: 20 mg/kg; 50 mg/kg
Administration: i.p.; administered immediately after the 3rd and 6th Caerulein injections and 2 h after the 7th injection (end of the 2nd, 5th, and 8th hour of the experiment).
Result: 50 mg/kg (three doses) significantly reduced CER-elevated serum amylase, pancreatic MPO activity, and overall histology score; trypsin also showed a marked reduction, while 20 mg/kg showed no significant effect.
Molecular Weight

755.28

Formula

C41H44ClFN6O5
SMILES

FC1=CC=C(C(N2CCCN2C([C@@H](NC(NCC3=CC4=C(N[C@H]5[C@H](O)CO[C@@H]4C5)C=C3)=O)C6=CC=C(C7=CC=C(CN8CCOCC8)C=C7)C=C6)=O)=C1)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CypD-IN-7 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CypD-IN-7CyclophilinCypD inhibitorPPIF inhibitorcyclophilin DPPIase inhibitormitochondrial permeability transition pore (MPTP/mPTP)calcium retention capacity (CRC)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CypD-IN-7
Cat. No.:
HY-179417
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.