Ric8a - RIC8 guanine nucleotide exchange factor A Gene

Also Known as Ric8; RIC-8

Species: Mus musculus

Gene Type: protein coding

Gene ID: 101489

Summary

Predicted to enable G-protein alpha-subunit binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including basement membrane organization; gastrulation; and visual learning. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Orthologous to human RIC8A (RIC8 guanine nucleotide exchange factor A). [provided by Alliance of Genome Resources, Apr 2022]

Ric8a Products (1)

mRNA	Protein	Name
NM_053194.4	NP_444424.1	synembryn-A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	22114146	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17593019	MGI
enables protein folding chaperone	IDA IDA: Inferred from direct assay	22114146	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22114146	MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	17593019	MGI
acts upstream of or within basement membrane organization	IMP IMP: Inferred from mutant phenotype	21069829	MGI
acts upstream of or within cell migration involved in gastrulation	IMP IMP: Inferred from mutant phenotype	21069829	MGI
acts upstream of or within cell-cell adhesion involved in gastrulation	IMP IMP: Inferred from mutant phenotype	21069829	MGI
acts upstream of or within gastrulation	IMP IMP: Inferred from mutant phenotype	21069829	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16221497	MGI
acts upstream of or within response to light stimulus	IMP IMP: Inferred from mutant phenotype	16221497	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	21069829	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	16221497	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	17593019	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	22114146	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
synembryn-A	resistance to inhibitors of cholinesterase 8 homolog synembryn

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122579	IGS-1.76	Inhibitor	98.57%	Unkown
HY-RS11967	RIC8A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121503	FD44		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ric8a	NCBI	NCBI:60626