ERP29 - endoplasmic reticulum protein 29 Gene

Also Known as ERp28; ERp31; PDIA9; PDI-DB; C12orf8; HEL-S-107

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10961

About ERP29

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,013,426-112,023,449 (from NCBI)

This gene has 5 transcripts (splice variants) and 136 orthologues. Ubiquitous expression in bone marrow (RPKM 73.5), prostate (RPKM 67.8) and 25 other tissues.

Summary

This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

ERP29 Products (2)

mRNA	Protein	Name
NM_001034025.2	NP_001029197.1	endoplasmic reticulum resident protein 29 isoform 2 precursor
NM_006817.4	NP_006808.1	endoplasmic reticulum resident protein 29 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22665516	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	22064321	GOA
involved in negative regulation of protein secretion	IDA IDA: Inferred from direct assay	22064321	GOA
acts upstream of or within positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	22064321	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	22064321	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	22064321	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	19995400	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	9738895	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERP29 Protein Structure

ERp29_N

ERp29

0
100
200
261 a.a.

Protein Preferred Names	Protein Names
endoplasmic reticulum resident protein 29	endoplasmic reticulum lumenal protein ERp28

ERP29 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ERP29	P30040	TTMP	Homo sapiens	Q5BVD1	Validated Y2H	32296183
Intra	ERP29	P30040	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	ERP29	P30040	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
Intra	ERP29	P30040	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	ERP29	P30040	TMBIM6	Homo sapiens	P55061	Validated Y2H	32296183
Intra	ERP29	P30040	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Intra	ERP29	P30040	TSPO2	Homo sapiens	Q5TGU0	Validated Y2H	32296183
Intra	ERP29	P30040	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	ERP29	P30040	DESI1	Homo sapiens	Q6ICB0	Validated Y2H	32296183
Intra	ERP29	P30040	HMG20B	Homo sapiens	Q9P0W2	Validated Y2H	32296183
Intra	ERP29	P30040	HMG20B	Homo sapiens	Q9P0W2	Y2H Prey Pooling	32296183
Intra	ERP29	P30040	HMG20B	Homo sapiens	Q9P0W2	Y2H Array	32296183
Intra	ERP29	P30040	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	ERP29	P30040	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	ERP29	P30040	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	ERP29	P30040	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	ERP29	P30040	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	ERP29	P30040	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	ERP29	P30040	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

ERP29 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82048	ERp29 Antibody (YA1793)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pharynx Squamous Cell Carcinoma
Gallbladder Adenocarcinoma	Adenocarcinoma Of The Gallbladder Carcinoma Of The Gallbladder
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04514	ERP29 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19191	Erp29 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25679	Erp29 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ERP29	VGNC	VGNC:40468
Felis catus	ERP29	VGNC	VGNC:80440
Bos taurus	ERP29	VGNC	VGNC:28596
Rattus norvegicus	ERP29	RGD	RGD:619781
Mus musculus	ERP29	MGD	MGI:1914647
Others	ERP29	NCBI