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ADPRH - ADP-ribosylarginine hydrolase Gene

Also Known as ARH1; hARH1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 141

About ADPRH

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:119,579,492-119,589,945 (from NCBI)

This gene has 7 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 7.2), spleen (RPKM 6.0) and 25 other tissues.

Summary

The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse Enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]

ADPRH Products (5)

mRNA	Protein	Name
NM_001125.4	NP_001116.1	ADP-ribosylarginine hydrolase isoform 1
NM_001291949.2	NP_001278878.1	ADP-ribosylarginine hydrolase isoform 1
NM_001291950.2	NP_001278879.1	ADP-ribosylarginine hydrolase isoform 2
NM_001371092.1	NP_001358021.1	ADP-ribosylarginine hydrolase isoform 1
NM_001391992.1	NP_001378921.1	ADP-ribosylarginine hydrolase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ADP-ribosylarginine hydrolase activity	IDA IDA: Inferred from direct assay	30472116	GOA
enables ADP-ribosylarginine hydrolase activity	IMP IMP: Inferred from mutant phenotype	8349667	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	19407395	GOA
enables potassium ion binding	IDA IDA: Inferred from direct assay	19407395	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein de-ADP-ribosylation	IDA IDA: Inferred from direct assay	30472116	GOA
involved in protein modification process	IMP IMP: Inferred from mutant phenotype	8349667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADPRH Protein Structure

ADP_ribosyl_GH

0
100
200
300
357 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylarginine hydrolase	ADP-ribose-L-arginine cleaving enzyme

ADPRH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADPRH	P54922	SPSB1	Homo sapiens	Q96BD6	Y2H Array	32296183
Intra	ADPRH	P54922	SPSB1	Homo sapiens	Q96BD6	Validated Y2H	32296183
Intra	ADPRH	P54922	SPSB1	Homo sapiens	Q96BD6	Y2H Prey Pooling	32296183
Intra	ADPRH	P54922	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
Intra	ADPRH	P54922	TFCP2	Homo sapiens	Q12800	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ADPRH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7462	ADPRH/ARH1 Protein, Human (His)	P54922 (M1-L357)	≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Tyrosinemia	Hypertyrosinemia Tyrosinemias Hereditary Tyrosinemia Hypertyrosinaemia Tyrosinaemia Hereditary Hypertyrosinemia
Glycine N-Methyltransferase Deficiency	GNMT DEFICIENCY Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency Hypermethioninemia Due To Gnmt Deficiency Hypermethioninemia Hepatic Methionine Adenosyltransferase Deficiency
Mucolipidosis Ii Alpha/Beta	I-Cell Disease Mucolipidosis Type Ii Mucolipidosis Ii Icd Inclusion Cell Disease Inclusion-Cell Disease I Cell Disease Mucolipidosis 2 MLII Ml Ii Ml Ii Alpha/Beta Gnpta Leroy Disease Ml 2 Ml Disorder Type 2 N-Acetylglucosamine 1phosphotransferase Deficiency Mucolipidosis Type Ii Alpha/Beta N-Acetylglucosamine 1-Phosphotransferase Deficiency Deficiency Of N-Acetylglucosamine-1-Phosphotransferase Mucolipidosis, Type Ii, Alpha/Beta Ml2 Type Ii Mucolipidosis
Sphingolipidosis	Sphingolipidoses
Arthrogryposis, Renal Dysfunction, And Cholestasis 1	Arc Syndrome ARCS1 Arthrogryposis Renal Dysfunction Cholestasis Syndrome Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome Arcs Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, And Cholestasis Arthrogryposis-Renal Dysfunction-Cholestasis Arthrogryposis - Renal Dysfunction - Cholestasis Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1 Arthrogryposis Renal Dysfunction And Cholestasis 1 Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1 Kidney Failure Renal Insufficiency
Stuttering	Stammering Familial Persistent Stuttering Stuttering, Familial Persistent 1
Leukodystrophy	Leukodystrophies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00404	ADPRH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18801	Adprh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25290	Adprh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADPRH	RGD	RGD:2052
Bos taurus	ADPRH	VGNC	VGNC:25690
Mus musculus	ADPRH	MGD	MGI:1098234
Macaca mulatta	ADPRH	VGNC	VGNC:110386
Canis familiaris	ADPRH	VGNC	VGNC:37670
Others	ADPRH	NCBI