EIF4G1 - eukaryotic translation initiation factor 4 gamma 1 Gene

Also Known as P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1981

About EIF4G1

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:184,314,606-184,335,358 (from NCBI)

This gene has 40 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 48.2), skin (RPKM 39.4) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for Other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

EIF4G1 Products (8)

mRNA	Protein	Name
NM_001194946.2	NP_001181875.2	eukaryotic translation initiation factor 4 gamma 1 isoform 6
NM_001194947.2	NP_001181876.2	eukaryotic translation initiation factor 4 gamma 1 isoform 6
NM_001291157.2	NP_001278086.2	eukaryotic translation initiation factor 4 gamma 1 isoform 7
NM_004953.5	NP_004944.3	eukaryotic translation initiation factor 4 gamma 1 isoform 4
NM_182917.4	NP_886553.3	eukaryotic translation initiation factor 4 gamma 1 isoform 1
NM_198241.3	NP_937884.2	eukaryotic translation initiation factor 4 gamma 1 isoform 5
NM_198242.3	NP_937885.1	eukaryotic translation initiation factor 4 gamma 1 isoform 3
NM_198244.3	NP_937887.2	eukaryotic translation initiation factor 4 gamma 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	25255371	GOA
enables eukaryotic initiation factor 4E binding	IDA IDA: Inferred from direct assay	23814182	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	24092755	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10523622	GOA
enables translation factor activity, RNA binding	IMP IMP: Inferred from mutant phenotype	18426977	GOA
enables translation initiation factor activity	IDA IDA: Inferred from direct assay	29987188	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to nutrient levels	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in macromolecule biosynthetic process	IGI IGI: Inferred from genetic interaction	18426977	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	23409027	GOA
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in positive regulation of eukaryotic translation initiation factor 4F complex assembly	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in positive regulation of eukaryotic translation initiation factor 4F complex assembly	IPI IPI: Inferred from physical interaction	23041282	GOA
involved in positive regulation of mRNA cap binding	IDA IDA: Inferred from direct assay	23409027	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in positive regulation of protein localization to cell periphery	IGI IGI: Inferred from genetic interaction	25533483	GOA
involved in positive regulation of protein metabolic process	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in positive regulation of translation in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	29062139	GOA
involved in regulation of presynapse assembly	IGI IGI: Inferred from genetic interaction	25533483	GOA
involved in regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	19648179	GOA
involved in translation	IMP IMP: Inferred from mutant phenotype	18426977	GOA
involved in translation	IPI IPI: Inferred from physical interaction	24092755	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	29987188	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17984221	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	18426977	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	17984221	GOA
part of eukaryotic translation initiation factor 4F complex	IDA IDA: Inferred from direct assay	25255371	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17984221	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	18426977	GOA
located in ribosome	IMP IMP: Inferred from mutant phenotype	18426977	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4G1 Protein Structure

MIF4G

MA3

0
300
600
900
1200
1500
1599 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 4 gamma 1	EIF4-gamma

EIF4G1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF4G1	Q04637	HNRNPD	Homo sapiens	Q14103-4	Pull Down	16556936
Intra	EIF4G1	Q04637	EIF4E	Homo sapiens	P06730	Pull Down	21191102
Intra	EIF4G1	Q04637	EIF4E	Homo sapiens	P06730	CoIP	15361857
Intra	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	SPR	19203580
Intra	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	Anti Bait CoIP	17353931
Intra	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	GMS	19203580
Intra	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	CoIP	11408474
Intra	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	NMR	19203580
Intra	EIF4G1	Q04637	EIF4A1	Homo sapiens	P60842	Pull Down	11408474
Intra	EIF4G1	Q04637	PABPC1	Homo sapiens	P11940	SPR	16772376
Intra	EIF4G1	Q04637	PABPC1	Homo sapiens	P11940	Pull Down	16772376
Intra	EIF4G1	Q04637	PABPC1	Homo sapiens	P11940	Pull Down	19716330
Intra	EIF4G1	Q04637	PABPC1	Homo sapiens	P11940	Pull Down	9857202

Cross: Cross-species interaction Intra: Intraspecies interaction

EIF4G1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80459	Phospho-eIF4G1 (Ser1108) Antibody (YA201)	WB, ICC/IF	Human
HY-P80652	eIF4G1 Antibody	WB, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Parkinson Disease 18, Autosomal Dominant	Parkinson Disease 18, Autosomal Dominant, Susceptibility To Parkinson Disease 18 PARK18 Parkinson Disease 18 Autosomal Dominant Parkinson Disease, Type 18
Hereditary Late-Onset Parkinson Disease	Autosomal Dominant Late-Onset Parkinson Disease Lopd Hereditary Late Onset Parkinson Disease
Mouth Disease	Mouth Diseases Mouth Disorders
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Poliomyelitis	Polio Infantile Paralysis
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Leukoencephalopathy With Vanishing White Matter	Cree Leukoencephalopathy Vanishing White Matter Disease Ovarioleukodystrophy Vanishing White Matter Leukodystrophy Childhood Ataxia With Central Nervous System Hypomyelinization Cach Cach Syndrome Myelinosis Centralis Diffusa VWM Cle Childhood Ataxia With Central Nervous System Hypomyelination Childhood Ataxia With Diffuse Central Nervous System Hypomyelination Cach/Vwm Cach/Vwm Syndrome Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter Cree Leukoencehalopathy Late Infantile Cach Syndrome Juvenile Or Adult Cach Syndrome Congenital Or Early Infantile Cach Syndrome Leukodystrophy With Vanishing White Matter
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19560	SBI-0640756	Inhibitor	99.75%	Unkown
HY-RS04281	EIF4G1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-164524	SBI-0640726	Inhibitor	99.57%	Unkown
HY-RS19254	Eif4g1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25743	Eif4g1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF4G1	RGD	RGD:1306144
Canis familiaris	EIF4G1	VGNC	VGNC:40289
Felis catus	EIF4G1	VGNC	VGNC:97415
Bos taurus	EIF4G1	VGNC	VGNC:28415
Macaca mulatta	EIF4G1	VGNC	VGNC:72195
Mus musculus	EIF4G1	MGD	MGI:2384784
Others	EIF4G1	NCBI