EIF4G1 - eukaryotic translation initiation factor 4 gamma 1 Gene

Homo sapiens

Also known as P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1

Gene ID: 1981 | Gene type: protein coding

About EIF4G1

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:184,314,606-184,335,358 (from NCBI)

This gene has 40 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in esophagus (RPKM 48.2), skin (RPKM 39.4) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

EIF4G1 Products(8)

mRNA	Protein	Name
NM_001194946.2	NP_001181875.2	eukaryotic translation initiation factor 4 gamma 1 isoform 6
NM_001194947.2	NP_001181876.2	eukaryotic translation initiation factor 4 gamma 1 isoform 6
NM_001291157.2	NP_001278086.2	eukaryotic translation initiation factor 4 gamma 1 isoform 7
NM_004953.5	NP_004944.3	eukaryotic translation initiation factor 4 gamma 1 isoform 4
NM_182917.4	NP_886553.3	eukaryotic translation initiation factor 4 gamma 1 isoform 1
NM_198241.3	NP_937884.2	eukaryotic translation initiation factor 4 gamma 1 isoform 5
NM_198242.3	NP_937885.1	eukaryotic translation initiation factor 4 gamma 1 isoform 3
NM_198244.3	NP_937887.2	eukaryotic translation initiation factor 4 gamma 1 isoform 2

EIF4G1 Protein Structure

MIF4G

MA3

0
300
600
900
1200
1500
1599 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 4 gamma 1

EIF4-gamma

Recombinant EIF4G1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71731	EIF4G1 Protein, Human (P.pastoris, His)	Q04637 (1250I-1599N)	≥95%

Related Diseases

Diseases

Alias

Parkinson Disease 18, Autosomal Dominant

Parkinson Disease 18, Autosomal Dominant, Susceptibility To	Parkinson Disease 18
PARK18	Parkinson Disease 18 Autosomal Dominant
Parkinson Disease, Type 18

Hereditary Late-Onset Parkinson Disease

Autosomal Dominant Late-Onset Parkinson Disease	Lopd
Hereditary Late Onset Parkinson Disease

Mouth Disease

Mouth Diseases

Mouth Disorders

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Poliomyelitis

Polio

Infantile Paralysis

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19560	SBI-0640756	Inhibitor	99.76%	Unkown
HY-RS04281	EIF4G1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF4G1	RGD	RGD:1306144
Canis familiaris	EIF4G1	VGNC	VGNC:40289
Felis catus	EIF4G1	VGNC	VGNC:97415
Bos taurus	EIF4G1	VGNC	VGNC:28415
Macaca mulatta	EIF4G1	VGNC	VGNC:72195
Mus musculus	EIF4G1	MGD	MGI:2384784
Others	EIF4G1	NCBI

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