2. Gene
  3. HYAL4 - hyaluronidase 4 Gene

HYAL4 - hyaluronidase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CSHY; HYAL-4

Gene ID: 23553 | Gene type: protein coding

About HYAL4

Cytogenetic location: 7q31.32 Genomic coordinates (GRCh38): 7:123,763,708-123,877,481 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a protein which is similar in structure to hyaluronidases but lacks hyaluronidase activity. The encoded protein acts as a chondroitin-sulfate-specific endo-beta-N-acetylgalactosaminidase; that is, it exhibits hydrolytic activity toward chondroitin sulfate chains and degrades them into oligosaccharides. Proteoglycans are formed by the covalent linkage of chondroitin sulfate chains to protein. Proteoglycans are ubiquitous components of the extracellular matrix of connective tissues and are also found at the surface of many cell types where they participate in a variety of cellular processes such as cell proliferation, differentiation, migration, cell-cell recognition, extracellular matrix deposition, and tissue morphogenesis. The expression of this gene is highest in testes and placenta. [provided by RefSeq, Apr 2019]

HYAL4 Products(1)

mRNA Protein Name
NM_012269.3 NP_036401.2 hyaluronidase-4

HYAL4 Protein Structure

Glyco_hydro_56

Glyco_hydro_56: Hyaluronidase (40 - 373)

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  • 481 a.a.
Protein Preferred Names Protein Names

hyaluronidase-4

chondroitin sulfate endo-beta-N-acetylgalactosaminidase

Related Diseases

Diseases Alias
Mucopolysaccharidosis, Type Ix

Mucopolysaccharidosis Type Ix

Hyaluronidase Deficiency

MPS9

Mps Ix

Mucopolysaccharidosis Ix

Mpsix

Mucopolysaccharidosis Type 9

Mucopolysaccharidosis 9
Hurler-Scheie Syndrome

Mucopolysaccharidosis Type Ih/S

Mucopolysaccharidosis Ih/S

MPS1H/S

Mpsih/S

Mucopolysaccharidosis Type 1h/S

Mps1-Hs

Alpha-L-Iduronidase Deficiency

Mucopolysaccharidosis I

Mucopolysaccharidosis 1h/S

Mps-Ih/S
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06498 HYAL4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HYAL4 MGD MGI:1924292
Bos taurus HYAL4 VGNC VGNC:53649
Felis catus HYAL4 VGNC VGNC:82482
Canis familiaris HYAL4 VGNC VGNC:41844
Rattus norvegicus HYAL4 RGD RGD:1303194
Macaca mulatta HYAL4 VGNC VGNC:81329