Cyp17a1 - cytochrome P450, family 17, subfamily a, polypeptide 1 Gene

Also Known as Cyp17

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25146

Summary

Enables steroid 17-alpha-monooxygenase activity. Involved in several processes, including animal organ development; response to fungicide; and response to Herbicide. Located in cell projection; endoplasmic reticulum; and neuronal cell body. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate Cancer. Orthologous to human CYP17A1 (Cytochrome P450 family 17 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp17a1 Products (1)

mRNA Protein Name
NM_012753.3 NP_036885.2 steroid 17-alpha-hydroxylase/17,20 lyase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables steroid 17-alpha-monooxygenase activity IDA
IDA: Inferred from direct assay
2786990 RGD
Biological Process GO Annotation Evidence References Source
involved in Leydig cell differentiation IEP
IEP: Inferred from expression pattern
18502897 RGD
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
17065412 RGD
involved in biphenyl metabolic process IEP
IEP: Inferred from expression pattern
20356859 RGD
involved in cellular response to antibiotic IEP
IEP: Inferred from expression pattern
18655822 RGD
involved in cellular response to gonadotropin stimulus IEP
IEP: Inferred from expression pattern
20963569 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
20665543 RGD
involved in dibenzo-p-dioxin metabolic process IEP
IEP: Inferred from expression pattern
20059580 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
21047951 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
10822021 RGD
involved in organic acid metabolic process IEP
IEP: Inferred from expression pattern
17400581 RGD
involved in phenol-containing compound metabolic process IEP
IEP: Inferred from expression pattern
18191889 RGD
involved in phthalate metabolic process IEP
IEP: Inferred from expression pattern
16809437 RGD
involved in positive regulation of steroid hormone biosynthetic process IMP
IMP: Inferred from mutant phenotype
19615041 RGD
involved in response to acetate IEP
IEP: Inferred from expression pattern
21046364 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
17291543 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
15958400 RGD
involved in response to fungicide IEP
IEP: Inferred from expression pattern
16214947 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
17291543 RGD
involved in response to herbicide IEP
IEP: Inferred from expression pattern
20667998 RGD
involved in response to insecticide IEP
IEP: Inferred from expression pattern
17569032 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
18821396 RGD
involved in response to methylmercury IEP
IEP: Inferred from expression pattern
17869401 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17936465 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18923996 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
19497980 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
19961867 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
17291543 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19603415 RGD
involved in steroid biosynthetic process IMP
IMP: Inferred from mutant phenotype
2786990 RGD
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
15934942 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15934942 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

steroid 17-alpha-hydroxylase/17,20 lyase

  • 17-alpha-hydroxyprogesterone aldolase

  • CYPXVII

  • Cytochrome P450, subfamily XVII

  • P450-C17

  • P45017alpha

  • P450c17

  • cytochrome P450 17A1

  • cytochrome P450, subfamily 17

  • cytochrome P450-C17

  • cytochrome P450c17

  • steroid 17-alpha-monooxygenase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-164457 ASN-001 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148430 4-Pyridylmethyl adamantanecarboxamide Inhibitor 99.83% Unkown
HY-181045 CYP17A1-IN-2 Inhibitor / Unkown
HY-163359 CYP17A1/HDAC6-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp17a1 NCBI NCBI:1586