Kcne1 - potassium voltage-gated channel subfamily E regulatory subunit 1 Gene

Also Known as Isk

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25471

Summary

Enables delayed rectifier Potassium Channel activity; Potassium Channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to acidic pH; negative regulation of protein targeting to membrane; and regulation of cation channel activity. Located in Z disc; apical plasma membrane; and endoplasmic reticulum. Part of voltage-gated Potassium Channel complex. Colocalizes with Golgi apparatus. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in Jervell-Lange Nielsen syndrome; atrial fibrillation; long QT syndrome; and long QT syndrome 5. Orthologous to human KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcne1 Products (1)

mRNA	Protein	Name
NM_012973.1	NP_037105.1	potassium voltage-gated channel subfamily E member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables delayed rectifier potassium channel activity	IMP IMP: Inferred from mutant phenotype	11810210	RGD
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	19219384	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14679187	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	20962273	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	19219384	RGD
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	11810210	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to acidic pH	IDA IDA: Inferred from direct assay	8458414	RGD
involved in cellular response to light stimulus	IEP IEP: Inferred from expression pattern	24202060	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	15389592	RGD
involved in negative regulation of delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	19219384	RGD
involved in negative regulation of protein targeting to membrane	IDA IDA: Inferred from direct assay	21943416	RGD
involved in negative regulation of voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	14679187	RGD
involved in positive regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	7957868	RGD
involved in positive regulation of voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	14679187	RGD
involved in positive regulation of voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	7568179	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Z disc	IDA IDA: Inferred from direct assay	11697903	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	2154581	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	19219384	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	15389592	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
potassium voltage-gated channel subfamily E member 1	IKs producing slow voltage-gated potassium channel subunit beta Mink delayed rectifier potassium channel subunit IsK minimal potassium channel mink potassium (K+) channel protein, slowly activating (Isk) potassium channel, voltage gated subfamily E r

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120960	N-Arachidonoyl-L-serine		98%	Unkown
HY-122504	Linoleoyl glycine	Inhibitor	/	Unkown
HY-184207	Zinc13732787	Inhibitor	/	Unkown
HY-RS07115	KCNE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcne1	NCBI	NCBI:3753