Sirt6 - sirtuin 6 Gene

Rattus norvegicus

Gene ID: 299638 | Gene type: protein coding

About Sirt6

Primary_assembly 7: 8,082,364-8,098,914 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 193 orthologues, 6 paralogues and is associated with 13 phenotypes.

Summary

Enables protein deacetylase activity. Involved in post-embryonic cardiac muscle cell growth involved in heart morphogenesis and response to nutrient levels. Located in cytoplasm and nucleus. Biomarker of non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Orthologous to human SIRT6 (Sirtuin 6). [provided by Alliance of Genome Resources, Apr 2022]

Sirt6 Products(1)

mRNA	Protein	Name
NM_001031649.1	NP_001026819.1	NAD-dependent protein deacetylase sirtuin-6

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107454	OSS_128167	Inhibitor	98.63%	Unkown
HY-115453	UBCS039	Activator	99.06%	Unkown
HY-148712	SIRT6 activator 12q	Activator	98.01%	Unkown
HY-153104	CrBKA		98.46%	Unkown
HY-156027	SIRT6-IN-3	Inhibitor	/	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sirt6	NCBI	NCBI:51548

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