Sirt6 - sirtuin 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 299638

About Sirt6

Primary_assembly 7: 8,082,364-8,098,914 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 193 orthologues, 6 paralogues and is associated with 13 phenotypes.

Summary

Enables protein deacetylase activity. Involved in post-embryonic cardiac muscle cell growth involved in heart morphogenesis and response to nutrient levels. Located in cytoplasm and nucleus. Biomarker of non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Orthologous to human SIRT6 (Sirtuin 6). [provided by Alliance of Genome Resources, Apr 2022]

Sirt6 Products (1)

mRNA Protein Name
NM_001031649.1 NP_001026819.1 NAD-dependent protein deacetylase sirtuin-6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22335191 RGD
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
22335191 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
30894089 RGD
involved in cellular response to endothelin IEP
IEP: Inferred from expression pattern
30894089 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
30894089 RGD
involved in post-embryonic cardiac muscle cell growth involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
22335191 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
22321393 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-6

  • NAD-dependent deacetylase sirtuin-6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107454 OSS_128167 Inhibitor 98.92% Unkown
HY-115453 UBCS039 Activator 98.88% Unkown
HY-N0010 Geniposidic acid Agonist 98.87% Unkown
HY-119376 MDL-800 Activator 99.11% Unkown
HY-148712 SIRT6 activator 12q Activator 99.83% Unkown
HY-103721 SIRT6-IN-2 Inhibitor 99.92% Unkown
HY-156757 MDL-811 Activator 99.68% Unkown
HY-16605 SIRT6-IN-6 Inhibitor 98.59% Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor 98.37% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-153104 CrBKA 98.46% Unkown
HY-178990 SIRT6-IN-5 Inhibitor / Unkown
HY-170402 SIRT6-IN-4 Inhibitor / Unkown
HY-177878 IMU-856 Modulator / Unkown
HY-182061 SIRT6 activator 3 Activator / Unkown
HY-169159 SIRT6 activator 2 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt6 NCBI NCBI:51548