2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. CrBKA

CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity.

For research use only. We do not sell to patients.

CrBKA Chemical Structure

CrBKA Chemical Structure

CAS No. : 2260810-48-6

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5 mg USD 310 In-stock
10 mg USD 500 In-stock
25 mg USD 1050 In-stock
50 mg USD 1700 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

CrBKA is a fluorogenic small-molecule substrate of SIRT6 with weak activity[1].

IC50 & Target[1]

SIRT6

 

Molecular Weight

505.56

Formula

C28H31N3O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CC=C(NC([C@H](CCCCNC(/C=C/C)=O)NC(OCC2=CC=CC=C2)=O)=O)C=C1O3)=CC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (197.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9780 mL 9.8900 mL 19.7800 mL
5 mM 0.3956 mL 1.9780 mL 3.9560 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9780 mL 9.8900 mL 19.7800 mL 49.4501 mL
5 mM 0.3956 mL 1.9780 mL 3.9560 mL 9.8900 mL
10 mM 0.1978 mL 0.9890 mL 1.9780 mL 4.9450 mL
15 mM 0.1319 mL 0.6593 mL 1.3187 mL 3.2967 mL
20 mM 0.0989 mL 0.4945 mL 0.9890 mL 2.4725 mL
25 mM 0.0791 mL 0.3956 mL 0.7912 mL 1.9780 mL
30 mM 0.0659 mL 0.3297 mL 0.6593 mL 1.6483 mL
40 mM 0.0495 mL 0.2473 mL 0.4945 mL 1.2363 mL
50 mM 0.0396 mL 0.1978 mL 0.3956 mL 0.9890 mL
60 mM 0.0330 mL 0.1648 mL 0.3297 mL 0.8242 mL
80 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.6181 mL
100 mM 0.0198 mL 0.0989 mL 0.1978 mL 0.4945 mL
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CrBKA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CrBKA2260810-48-6SirtuinInhibitorinhibitorinhibit

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