2. Gene
  3. Plekhg5 - pleckstrin homology and RhoGEF domain containing G5 Gene

Plekhg5 - pleckstrin homology and RhoGEF domain containing G5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Tech

Gene ID: 310999 | Gene type: protein coding

About Plekhg5

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including endothelial cell chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB signaling; and regulation of protein catabolic process at presynapse, modulating synaptic transmission. Predicted to be located in cell-cell junction; cytoplasm; and lamellipodium. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and distal spinal muscular atrophy type 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). [provided by Alliance of Genome Resources, Apr 2022]

Plekhg5 Products(1)

mRNA Protein Name
NM_201272.2 NP_958429.1 pleckstrin homology domain-containing family G member 5
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16467373 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family G member 5

PH domain-containing family G member 5

neuronal RhoA GEF protein

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

transcript highly enriched in cortex and hippocampus

Plekhg5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Plekhg5 Q6RFZ7 Gipc1 Rattus norvegicus Q9Z254
Anti Bait CoIP
16467373
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10693 PLEKHG5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14813 TNFRSF25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plekhg5 NCBI NCBI:57449