Plekhg5 - pleckstrin homology and RhoGEF domain containing G5 Gene

Also Known as Tech

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 310999

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including endothelial cell chemotaxis; positive regulation of I-kappaB kinase/NF-kappaB signaling; and regulation of protein catabolic process at presynapse, modulating synaptic transmission. Predicted to be located in cell-cell junction; cytoplasm; and lamellipodium. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and distal spinal muscular atrophy type 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). [provided by Alliance of Genome Resources, Apr 2022]

Plekhg5 Products (1)

mRNA Protein Name
NM_201272.2 NP_958429.1 pleckstrin homology domain-containing family G member 5

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16467373 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family G member 5

  • PH domain-containing family G member 5

  • neuronal RhoA GEF protein

  • pleckstrin homology domain containing, family G (with RhoGef domain) member 5

  • transcript highly enriched in cortex and hippocampus

Plekhg5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Plekhg5 Q6RFZ7 Gipc1 Rattus norvegicus Q9Z254
Anti Bait CoIP
16467373
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10693 PLEKHG5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14813 TNFRSF25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plekhg5 NCBI NCBI:57449